L-赖氨酸-Sepharose 4B吸附纤溶酶原及纤溶酶  

Adsorb fibrinolysin and profibrinolysin with L-Lysine-Sepharose 4B

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作  者:王期中 李西河 徐贯芬 庞广礼 

机构地区:[1]山东省生物制品研究所,泰安271000

出  处:《药学实践杂志》1997年第2期90-92,共3页Journal of Pharmaceutical Practice

摘  要:本次研究为了解决人血丙种球蛋白制品因纤溶酶原及纤格酶引起的IgG裂解问题,采用了L-赖氨酸与Sepharose4B偶联后吸附制品中纤溶酶原及纤溶酶。结果表明,人血丙种球蛋白中纤港酶原及纤溶酶被吸附。被吸附过的制品与未被吸附过的制品相比较其裂解程度显著降低。因此,在人血丙种球蛋白生产工艺中,加入L-赖氨酸-Sepharose4B吸附纤溶酶原和纤溶酶,可明显提高产品稳定性,解决人血丙种球蛋白裂解的问题,可提高产品的稳定性。To increase stability and to solve the problem of splitting of human secrum γ -globulin products, we were used to adsorb fibrinolysin and profibrinoly8in with L - Lysine -Sepharose 4B. The Result shows that fibrinolysin and profibrinolysin in the human secrum γ -globulin products are adsorpted. Compared with the unadsorbed products, the splitting degree ofthe adsorbed products was decreased obviosly. In manufacture production of human secrum γ -globulin products, adsorbing fibrinolysin and profibrinolysin with L - Lysine - sepharose 4B mayincrease stability of human secrum γ - globulin and solve splitting problem of the product. It is aeffective method to improv the production quality.

关 键 词:人血丙种球蛋白 赖氨酸 Sepharose4B 纤溶酶 

分 类 号:R392-33[医药卫生—免疫学]

 

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