半边旗5F对人病理性瘢痕动物模型生物性状的影响  

Effects of 5F from Peris semipinnate L on growth of human pathological scars in nude mice

作　　者：张云松[1] 何井华[2] 罗少军[3] 李叶扬[1] 梁岷[1] 

机构地区：[1]广州市红十字会医院 [2]南方医科大学珠江医院,广东广州510282 [3]广东医学院整形研究所,广东湛江524023

出　　处：《南方医科大学学报》2007年第11期1677-1680,共4页Journal of Southern Medical University

基　　金：广东省重点学科资金(9306);广东省卫生厅科研项目(A2003654);广州市中医药中西医结合科研项目(2005A023)

摘　　要：目的观察5F对人病理性瘢痕裸鼠模型瘢痕组织生物性状的影响。方法以人病理性瘢痕移植于裸鼠建立动物模型,分别用不同浓度5F作用于动物模型,观察其形态学、组织学、瘢痕组织中TGF-β1及Ⅰ型胶原含量的改变。结果5F能使动物模型瘢痕体积缩小,组织结构向普通瘢痕转化,降低瘢痕中TGF-β1及I型胶原含量。结论5F能明显抑制瘢痕动物模型组织的生长,在病理性瘢痕的治疗中可能有潜在的应用价值。Objective To investigate the effect of 5F from Peris sernipinnate L on the growth of human pathological scar in nude mice. Methods 5F from Peris semipinnate L was administered at different doses in nude mouse models bearing human pathological scars. The morphology, histology, tumor growth factor-β1 and type I collagen content of the scar tissues were examined after the administration. Results Administration of 5F significantly reduced the volume of the impanted pathological scars in the nude mouse models, and histologically, the scar tissue exhibited a transition to the normal scar architecture with decreased TGF-β1 and type Ⅰ collagen content. Conclusion 5F could effectively inhibit the growth of pathological scars in nude mice.

关 键 词：半边旗 病理性瘢痕 动物模型 

分 类 号：R285.5[医药卫生—中药学]