阿托伐他汀对慢性心力衰竭作用观察  

Atorvastatin for improving cardiac function in patients with chronic heart failure

作　　者：霍永生[1] 章辉[1] 蒋静涵[1] 王伟华[1] 

机构地区：[1]皖南医学院附属弋矶山医院急诊内科,安徽芜湖241001

出　　处：《皖南医学院学报》2007年第4期270-272,共3页Journal of Wannan Medical College

摘　　要：目的:探讨他汀类药物治疗慢性心力衰竭的有效性。方法:选择慢性心力衰竭患者82例,随机分为两组,对照组给予强心剂、利尿剂、β-受体阻滞剂、血管紧张素转换酶抑制剂或血管紧张素受体拮抗剂等常规治疗,治疗组在上述治疗的基础上加服阿托伐他汀10 mg/日,每月门诊随访,分别于治疗前、治疗后3月和6月进行心功能分级、测量左室射血分数(LVEF)、左室舒张末容积指数(LVEDVI)、左室收缩末容积指数(LVESVI),同时观察再入院率及病死率。结果:治疗组在治疗后6个月心功能、LVEF、LVEDVI、LVESVI较对照组有明显改善,再住院率减少,与对照组比较有显著性差异。结论:阿托伐他汀可有效改善心功能,减少再住院率及病死率。Objective：To study short-term effect of stains on patients with chronic heart failure by reviewing the changes of heart function after treatment. Methods ： Eighty-two paients with chronic heart failure were randomly allocated to medication group（ 77 = 41 ） and control subjects（ n = 41 ）. The control group were treated conventionally with cardiotonic, diuretic agent, β-receptor blocking agent, angiotensin converting enzyme inhibitor or receptor antagonist, and besides, the medication group received aorvasta 10 mg/d for 12 weeks with monthly counseling of out-paient. Before and after 3 or 6 months of treatment, the LVEF, LVEDVI and LVFSVI were measured and analyzed, and readmission and faality rate were reviewed as well. Results ： After 6 months of therapy, patients receiving atorvasta exhibited a mcxtcst reduction in LVEF, LVEDVI, LVESVI and relapse compared with control group （P 〈 0.05）. Conclusion ：Fewer readmission and case fatality show that short-term atorvastain Inay improve cardiac function.

关 键 词：慢性心力衰竭 他汀类药物 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]