腹腔注入乳酸钠林格液对大鼠肝肾血流动力学的影响  

Hepatic and renal hemodynamics affected by sodium lactate ringer′s injection in rats

作　　者：许立龙[1] 李国杰[2] 朱向明[2] 赵博文[1] 吴赤球 

机构地区：[1]浙江大学医学院附属邵逸夫医院超声科,浙江杭州310016 [2]皖南医学院附属弋矶山医院超声医学科,安徽芜湖241000 [3]武警杭州医院特检科,浙江杭州310010

出　　处：《皖南医学院学报》2007年第4期299-301,共3页Journal of Wannan Medical College

摘　　要：目的:探讨腹腔介质增强超声显像技术安全性,为其临床应用提供一定的实验性依据。方法:健康SD大鼠50只,雌雄各半,随机分为5组,A组:正常对照组;B、C、D、E组分别为腹腔注入乳酸钠林格液后10 min组、1 h组、24 h组及7 d组。对5组大鼠分别进行超声检测:测量肝脏门静脉(PV)的内径,监测肝门静脉最高流速(Vmax)、肝固有动脉(HA)的收缩期血流峰值速度(Vmax)、舒张末期血流速度(Vmin)、阻力指数(RI);肾主、肾段动脉的收缩期峰值血流速度(Vmax)、舒张末期血流速度(Vmin)、阻力指数(RI)等。结果:各实验组与正常对照组比较:超声监测大鼠肝脏PV内径及各项血流动力学指标差异无显著性意义(P>0.05);各实验组与正常对照组比较:肾脏血流动力学各项指标差异亦无显著性意义(P>0.05)。结论:腹腔注水成像技术是一种较为安全的超声增强显像技术。Objective： To evaluate the safety by using intra-abdorninal medium enhancement in ultrasonic imaging technology. Methods ： Fifty healthy SD rats were randomly divided into group A（normal control group）,B, C, D and E. Group B, C, D and E were injected with sodium lactate ringer＇s injection into abdominal cavity of the animals for the test of after 10min, 1 h, 24 h and 7 days, respectively. The rats in 5 groups were singly examined by ultrasonography for measuring the internal diameter and maximum flow of hepatic portal venous, peak blood flow volume in systolic phase, minimum velocity at end-diastolic phase and resistant index of hepatic artery, and the measurement was done on aorta and segmental renal artery. Results ： The hepatic and renal hernodynarnic indexes of all experimental groups showed no significant difference compared with control group （P 〉0. 05 ）. Conclusion lntra-abdorninal medium enhancement in ultrasonic imaging technology can be safe in clinic.

关 键 词：大鼠 肾脏 肝脏 超声描记术 血流动力学 平衡液 

分 类 号：R445.1[医药卫生—影像医学与核医学]