美味猕猴桃根提取物的体内抗肿瘤作用研究  

Study on Anti-tumor Effect of Extractions from Roots of Actinidia deliciosa

作　　者：梁洁[1] 王新盛[1] 甄汉深[1] 钟振国[1] 张雯艳[1] 张薇薇[1] 李吾来[1] 

机构地区：[1]广西中医学院药学院,广西南宁530001

出　　处：《中药材》2007年第10期1279-1282,共4页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金地区联合资助项目(30160095);国家人事部留学回国人员资助项目(人发[2002]99号);广西新世纪十百千人才工程资助项目(2001209)

摘　　要：目的:研究美味猕猴桃根的乙酸乙酯提取物(Actinidia deliciosaethyl acetate extracts,ADEE)和正丁醇提取物(Actinidia deliciosan-butanol extracts,ADBE)体内抗肿瘤作用。方法:建立S180小鼠肉瘤和H22肝癌腹水瘤模型,观察乙酸乙酯提取物和正丁醇提取物对S180荷瘤小鼠肉瘤生长的抑制作用和对H22肝癌腹水瘤小鼠生命的延长作用,并观察其对胸腺和脾脏免疫器官重量的影响。结果:乙酸乙酯提取物和正丁醇提取物对S180实体瘤的生长有显著的抑制作用(P<0.05,P<0.01),能够明显延长H22肝癌腹水瘤小鼠生命存活时间(P<0.05,P<0.01),并具有一定的免疫促进作用。结论:美味猕猴桃根的乙酸乙醇提取物和正丁醇提取物在小鼠体内具有明显的抗肿瘤作用。Objective： To study the anti-tumor effect of ADEE and ADBE in mice. Methods： The models of S180 entity tumor mice and H22 hearing tumor mice were established to obselwe the effect of ADEE and ADBE on inhibiting S180 entity tumor growth and prolonging life time of H22-mice, and the effect on spleen and thymus index to S180 entity tumor. Results ： Both ADEE and ADBE had obvious anti-tumor effects to S180-mice （ P 〈 0. 05, P 〈 0. 01 ） and could prolong H22-mice life （ P 〈 0. 05, P 〈 0. 01 ）. In certain degree, ADEE and ADBE could improve the immune function of bearing tumor mice. Conclusion：ADEE and ADBE have obvious anti-tumor effect.

关 键 词：美味猕猴桃根 提取物 抗肿瘤作用 免疫功能 

分 类 号：R285.5[医药卫生—中药学]