应用复仙安预防普外科围手术期感染的临床随机研究  

A randomized control study on the clinical effects of Cefotiam in prophylaxis of perioperative infection

作　　者：林雨冬[1] 王星[1] 王明元[1] 杨永锐[1] 吴德柱[1] 黄春开[1] 

机构地区：[1]南京军区总医院95临床部外科,531100

出　　处：《临床外科杂志》2007年第10期676-677,共2页Journal of Clinical Surgery

摘　　要：目的探讨复仙安（头孢替安）用于普外科围手期手术感染预防的可靠性。方法随机将我院普外科收治的I、Ⅱ类手术患者1108例分为两组，实验组632例，术前30min内应用复仙安（0．5～2．0g），溶于5％葡萄糖溶液静脉滴注，单次冲击给药；对照组476例，术前30min内应用头孢呋辛1．5g，溶于5％葡萄糖溶液静脉滴注，单次冲击给药。结果实验组术后最高体温（37．22±0．31）℃。退热时间（33．36±27．64）h；对照组术后最高体温（37．84±0．28）℃，退热时间（33．41±28．73）h。最高体温两组间差异和退热时间两组间差异均不具有统计学意义（P〉0．05）。两组均可耐受，无严重不良反应发生。结论复仙安术前单次冲击给药可安全有效用于普外科围手术期多种感染的预防。Objective To explore the reliability of Cefotiam to prevent periopeative inflection. Methods In a randomized control study,a total of 1108 inpatients undergoing type Ⅰ or type Ⅱincision operations in general surgery of our hospital were randomly divided into experimental group receiving Cefotiam （ n = 632） and control group receiving cefuroxime （ n = 476）. Results In experimental group and control group, the maximum temperature after operationwas （37.22± 0.31）℃and （37.84± 0.28）℃ ,and the defervesee time was （33.36 ± 27.64）h and （33.41 ± 28.73）h respectively （ P〉 0.05）. There were no severe adverse events in two groups. Conchlsion Periopeative Application of single administration of cefotiam is a rational effective and safe prophylactic regime to prevent postoperative infection.

关 键 词：头孢替安 外科 围手术期 预防性用药 

分 类 号：R619[医药卫生—外科学]