孔数不同的软骨下骨钻孔术对兔软骨缺损修复的影响  

Influence of Subchondral Drilling With Different Number of Holes on The Repair of Articular Cartilage Defect in Rabbits

作　　者：葛志强[1,2,3] 冯传汉[1,2,3] 吕厚山 曲月波[1,2,3] 雷学锋 杨洪峰[1,2,3] 曹化祥 廉平[1,2,3] 李咸周 邢凤石[1,2,3] 

机构地区：[1]济宁医学院外科教研室 [2]北京医科大学人民医院骨科 [3]济宁卫生学校外科

出　　处：《中华骨科杂志》1997年第6期389-391,共3页Chinese Journal of Orthopaedics

基　　金：美国CMB基金

摘　　要：目的：为了观察软骨缺损的修复过程，比较不同数目钻孔术对软骨缺损的修复效果。方法：用中国白兔２４只，在股骨关节面造成６ｍｍ×８ｍｍ全层软骨缺损，分别施行１０孔及５孔钻孔术，术后４、８周取材，做组织学及电镜观察，并进行评估。结果：（１）１０孔、５孔和对照组的优势修复组织分别以类透明软骨，类透明软骨加纤维软骨和纤维组织为主。（２）修复组织厚度１０孔及５孔无显著差异。（３）修复组织覆盖缺损的面积，１０孔＞５孔＞对照组。初步结论：软骨下骨钻孔可修复关节软骨全层缺损；多孔比少孔修复好；非钻孔的缺损修复效果较差。In order to observe the procees of repairing articular cartilage defect and compare the effect of repairing after subchondral drilling with different holes. Methods: Full thickness defects of 6mm×8mm were created over the articular suface of both the femoral condyles in 24 rabbits. The 10 and 5 holes were drilled respectively over the defects with the exception of those of the control ones. They were sacrificed postoperatively at the end of 4 and 8 weeks. The newly formed tissue in the defects were examined histologically and ultrastructurally. The effect of repair defect in different groups was compared and evaluated. Results: Hyalin like cartilage was formed in the 10 holes group, hyalin like caetilage or fibrous cartilage was identifid in the 5 holes one. and the fibrous tissues was found in the controls. The thickness of repair tissues had no significant difference between the 10 holes and 5 holes group. The coreved areas of repair tissue of the 10 holes group exceeded those of 5 holes and control ones. Preliminary concluded: Subchondral bone drilling is feasible for repairing full thickness articular cartilage defects. The repair effect of 10 holes is superior to that of 5 holes. When the defects are not drilled, the tissue regeneration is much less and the repair in sufficient.

关 键 词：关节软骨 软骨缺损 钻孔术 

分 类 号：R684.05[医药卫生—骨科学]