聚合物支载的L-脯氨酸催化的直接不对称Aldol反应  

Synthesis of Polymer-supported L-proline Catalyst and Study on Their Catalyzed Direct Asymmetric Aldol Reaction

作　　者：张宝华[1] 史兰香[2] 

机构地区：[1]石家庄学院物理系,河北石家庄050035 [2]石家庄学院化工学院,河北石家庄050035

出　　处：《河北师范大学学报（自然科学版）》2007年第6期768-771,783,共5页Journal of Hebei Normal University：Natural Science

基　　金：国家自然科学基金(20572004);河北省科学技术厅科学研究基金(07215603D)

摘　　要：制备了3种聚合物支载的L-脯氨酸催化剂6a^6c.以4-硝基苯甲醛、丙酮的Aldol反应为模型对它们的催化活性进行了筛选,6b为最佳催化剂,它催化的醛与丙酮的直接不对称Aldol反应(收率60%~68%,62%~82%ee)与L-脯氨酸催化的该反应(收率60%~68%,60%~85%ee)相当.6b可以通过结晶回收套用,反复使用5次催化效率不变.DMF,DMSO是最合适溶剂,催化剂用量以n(催化剂)∶n(醛)=1∶4最佳.Three kinds of polymer-supported catalysts loaded L-proline 6a--6c were prepared and their catalytic activity were screened by the direct asymmetric aldol reaction of acetone and 4-nitrobenzaldehyde. The catalyst 6b was the best one among them. The yields and ee values （yield 60 %-68 %, 62 %--82 % ee） catalyzed by 6b were as well as that of L-proline （yield 60 % -68 % ,60 % -85 %ee）. 6b could be recoveried and reused by crystallization,and after reuse of the catalyst five times, there was no loss in activity. The DMSO and DMF was the suitable solvent and n （catalyst） ： n （aldehyde）=1：4 was best.

关 键 词：直接不对称ALDOL反应 L-脯氨酸 聚合物支载的催化剂 

分 类 号：O621.34[理学—有机化学]