艾可清胶囊联合高效抗病毒逆转录疗法治疗艾滋病临床观察  

Clinical Observation on Aikeqing Capsule Combined with Highly Active Antiretroviral Therapy for the Treatment of Acquired Immunodeficiency Syndrome

作　　者：马伯艳[1] 符林春[1] 蔡卫平[2] 陈谐捷[2] 胡英杰[1] 谭行华[2] 

机构地区：[1]广州中医药大学热带医学研究所,广州510405 [2]广州市第八人民医院感染科,广州510060

出　　处：《广州中医药大学学报》2007年第6期466-470,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：教育部科学技术研究重点项目(编号:02109);广东省科技计划资助项目(编号:2003C33904);广东省中医药管理局资助项目(编号:203105);广州市卫生局科研重点项目资助(编号:2004);广州中医药大学博士后科技基金资助项目(编号:2005)

摘　　要：【目的】评价艾可清胶囊联合高效抗病毒逆转录疗法(highly active antiretroviral therapy,HAART)治疗艾滋病(AIDS)患者的有效性和安全性。【方法】将18例患者随机分为2组,每组9例。治疗组在HAART治疗的同时加用中药艾可清胶囊,对照组只给予HAART治疗。分别在治疗前、治疗3个月和治疗6个月检测T淋巴细胞亚群,记录症状体征积分(积分1)和症状舌脉积分(积分2),观察体质量和生存质量(卡洛夫斯基积分,Karnovsky Score),检测血常规、肝功能、肾功能及血清淀粉酶以评价艾可清胶囊的安全性。【结果】两组T淋巴细胞亚群各项指标在治疗后均有所改善(P<0.05或P<0.01),但各评价点两组间比较无显著性差异(P>0.05)。治疗组治疗后各评价点证候、体征积分均较对照组下降(P<0.05),卡洛夫斯基积分及体质量较对照组增加(P<0.05或P<0.01)。加用艾可清胶囊未见血常规、肝肾功能及血清淀粉酶异常变化。【结论】艾可清胶囊可有效、安全地缓解因HAART引起的不良反应。[ Objective ] To evaluate the therapeutic effect and safety of Aikeqing Capsule （AC） combined with highly active antiretroviral therapy （HAART） for the treatment of acquired immunodeficiency syndrome （AIS）. [ Methods ] Eighteen AIDS patients were equally randomized into two groups. Both of Groups A and B were given HAART, and group A received AC additionally. T lymphocyte subtypes were detected, scores of symptoms and signs and scores of symptoms and tongue feature as well as pulse condition were counted, body weight was examined and quality of life was evaluated with Karnovsky score before treatment and after treatment for 3 months and 6 months. Meanwhile, blood routine analysis, hepatic function, renal function and serum amylase content were examined to evaluate the safety of AC. [ Results ] After treatment, T lymphocytes subtypes were improved in the two groups （P 〈 0. 05 or P 〈 0. 01 ） as compared with those before treatment but the difference was insignificant between the two groups （P 〉 0. 05）. In group A, symptoms and signs scores decreased （P 〈 0. 05）, and Karnovsky score and body weight increased as compared with group B （P 〈 0.05 or P 〈 0.01 ）. No abnormal changes of blood routine analysis, hepatic function, renal function and serum amylase content was found in group A. [ Conclusion ] AC can effectively relieve the adverse reaction induced by HAART.

关 键 词：艾滋病/中西医结合疗法 人类免疫缺陷病毒/药物作用 艾可清/治疗应用 高效抗病毒逆转录疗法 安全性评价 

分 类 号：R521.91[医药卫生—内科学]