疏肝和胃颗粒对行为绝望小鼠的抗抑郁作用  

Anti-depression Effect of Shugan Hewei Granules on Mice with Behavioral Despair

作　　者：马淑雯[1] 熊天琴[2] 韦史利[1] 郭谦[3] 赵学军[1] 

机构地区：[1]广州中医药大学新药开发研究中心,广州510405 [2]广州中医药大学中药学院,广州510405 [3]广州军区直属第一门诊部,广州510080

出　　处：《广州中医药大学学报》2007年第6期476-477,482,共3页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】观察疏肝和胃颗粒对行为绝望模型小鼠的抗抑郁作用。【方法】将昆明系小鼠随机分为5组:模型组,疏肝和胃颗粒低、中、高剂量组(中药低、中、高剂量组的剂量分别为0.25、0.5、1.0 g.kg-1.d-1),氯丙米嗪组(剂量为0.04 g.kg-1.d-1);采用小鼠悬尾和强迫游泳实验观察各组小鼠不动时间。【结果】中药中、高剂量可显著性缩短小鼠悬尾和游泳不动时间(P<0.05或P<0.01),且呈一定的剂量效应关系。【结论】疏肝和胃颗粒对行为绝望模型小鼠具有一定的抗抑郁作用。[ Objective] To observe the anti-depression effect of Shugan Hewei Granules （SHG） on mice with behavioral despair. [ Methods ] Kunming mice were randomized into 5 groups ： model group, low-, moderate- and high-dose SHG groups （ in the dosages of 0.25, 0. 5 and 1.0 g· kg^-1 . d^-1 respectively） and chloropromazine （CP） group . Tail suspension test and forced swimming test were used to investigate immobility time of mice. [ Results ] Moderate- and high-dose SHG shortened the immobility time obviously during tail suspension test and forced swimming test （P 〈 0. 05 or P 〈 0.01 compared with the model group ） in a dose-effect manner. [ Conclusion] SHG exerts a certain anti-depression effect on mice with behavioral despair.

关 键 词：疏肝和胃颗粒/药理学 抑郁证/中药疗法 疾病模型 动物 小鼠 

分 类 号：R285.5[医药卫生—中药学]