总胆汁酸测定对婴幼儿肝炎综合征诊断价值的探讨  

Clinical analysis of serum total bile acid determination in diagnosis of infantile hepatitis syndrome

作　　者：卿文衡 

机构地区：[1]湖南省衡阳市中心医院检验科,421001

出　　处：《检验医学与临床》2007年第10期942-943,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨血清总胆汁酸(TBA)在婴幼儿肝炎综合征中的诊断价值。方法采用全自动酶循环法分析技术对52例婴幼儿肝炎综合征及60例健康对照组的婴幼儿进行空腹血清TBA及其他肝功能6项指标测定。结果健康对照组血清TBA值频数呈正偏态分布,经对数转换后,正态性D检验呈对数正态分布,参考值范围:0～11.6μmol/L。患儿组血清TBA值范围:1.1～239.6μmol/L,异常率达90.4%,与健康对照组比较,差异有统计学意义(P<0.05);患儿组TBA与血清碱性磷酸酶、直接胆红素、γ-谷氨酰转移酶水平有良好的相关性,且TBA的灵敏度和特异性均优于常规指标。结论血清TBA测定对婴幼儿肝炎综合征的诊断、疗效观察及预后判断均有重要意义。Objective To investigate the diagnostic value of serum total bile acid （TBA） determination in infantile hepatitis syndrome. Methods Serum TEA and other liver function related items were measured by automatic enzymatic assay techniques in 52 children with infantile hepatitis syndrome （disease group） and 60 healthy infants （control group）. Results The frequency of serum TEA value presented skewness distribution in healthy control group. After logarithm transformation, the normality D-test displayed the logarithm normal distribution. In control group, the range of serum TBA was 0-11.6 μmol/L. TEA level was abnormal in 90.4% patients and the value range was 1.1-239.6 μmol/L. The difference was significant between the two groups （P〈0.05）. In disease group, the TEA level was closely related to ALP, DBIL and γ-GT, and the sensitivity and specificity of TEA were superior to the other conventional indice. Conclusion Serum TEA determination plays an important role in diagnosis, therapeutic effect observation and prognosis evaluation of infantile hepatitis syndrome.

关 键 词：胆汁酸 肝炎综合征 酶循环法 

分 类 号：R446.11[医药卫生—诊断学]