2-脱氧-L-核糖的合成方法改进  

Improvement on Synthesis of 2-Deoxy-L-ribose

作　　者：叶素梅[1] 任宇红[1] 魏东芝[1] 

机构地区：[1]华东理工大学生物反应器工程国家重点实验室,上海200237

出　　处：《精细化工》2007年第11期1099-1101,1105,共4页Fine Chemicals

摘　　要：以L-阿拉伯糖为起始物,通过羟基保护、还原、脱保护等5步反应得到一种重要的L-脱氧核苷类药物中间体2-脱氧-L-核糖。在最后一步脱保护过程中,改用在醋酸水溶液中脱去苯甲基保护基团,单步产率由70%提高到92%,总收率提高到40%。化合物的结构用1HNMR、MS及元素分析法进行了表征。2-Deoxy-L-ribose, an important intermediate of L-deoxynucleosides, was obtained by five steps reaction with L-arabinose as the starting material. In the last deprotection step we used acetic acid/water solution to take off the benzyl radical, the yield of the single step was increased from 70% to 92% ,and the overall yield was increased to 40%. Structures of the compounds were identified by ^1HNMR,MS and elementary analysis.

关 键 词：2-脱氧-L-核糖 L-脱氧核苷类药物 抗病毒活性 药物中间体 

分 类 号：TE665.3[石油与天然气工程—油气加工工程] O621.3[理学—有机化学]