特发性血小板减少性紫癜血清β_2微球蛋白及细胞因子水平变化的意义  

Significance of Changes of Serum Beta 2-Microglobulin,Cytocine Levels in Childhood Idiopathic Thrombocytopenic Purpura

作　　者：魏金铠[1] 杨小巍[1] 刘玉环[1] 石瑄[1] 许月红[1] 

机构地区：[1]河北大学附属医院儿科,河北保定071000

出　　处：《实用儿科临床杂志》2007年第21期1625-1626,共2页Journal of Applied Clinical Pediatrics

基　　金：河北省科学技术研究与发展指导计划项目资助(052761714)

摘　　要：目的探讨特发性血小板减少性紫癜(ITP)患儿血清β2微球蛋白(β2-MG)及淋巴细胞因子白细胞介素-2(IL-2)水平及意义。方法选择ITP儿童110例作为病例组。其中初发病例70例,复发病例40例。健康儿童110例作为健康对照组。均抽血应用放射免疫分析试剂盒检测其血清β2-MG、IL-2水平,并应用两样本成组t检验进行比较。结果与健康儿童比较,ITP患儿血清β2-MG显著升高(P<0.01),IL-2水平显著降低(P<0.01),复发与初发患儿比较,无显著性差异(P>0.05)。结论检测ITP患儿血清β2-MG、IL-2水平对反映其病情变化、指导治疗有重要意义。Objective To study the changes mad significance of serum beta 2 - microglobulin （ β2 - MG）, cytocine interleukin - 2 （ IL - 2 ） in the clinical progress of childhood idiopathic thrombocytopenic purpura （ITP）, Methods One hundred and ten patients of childhood ITP were chosen for the test group（70 cases of primary ITP and 40 cases of recurrent ITP） ,and 110 normal children for the control group. Levels of serum β2 - MG and IL - 2 were determined by radioimmunoassay kit and analysed with two sample t - test, Results Among the patients, the serum IL - 2 levels were significantly lower and serum β2 - MG levels were significantly higher than those in control group（ P 〈 0, 01 ）. The serum IL - 2, β2 - MG levels in primary ITP were not significantly different from those in the recurrent ITP（ P 〉 0.05 ）. Conclusion Determining serum IL - 2 and β2 - MG levels has important significance to reflect the progress of disease and direct treatment.

关 键 词：紫癜 血小板减少性 特发性 Β2微球蛋白 白细胞介素-2 儿童 

分 类 号：R725.5[医药卫生—儿科]