腹膜透析液添加葛根素对氧化应激状态的影响  

Puerarin ameliorates oxidative stress in patients undergoing continuous ambulatory peritoneal dialysis

作　　者：孙琤[1] 张苗[1] 蒋春明[1] 

机构地区：[1]南京大学医学院附属鼓楼医院肾脏内科,江苏南京210008

出　　处：《医学研究生学报》2007年第11期1175-1178,共4页Journal of Medical Postgraduates

基　　金：南京市医学科技发展重点项目基金资助(批准号:ZKX0416)

摘　　要：目的:观察在腹膜透析(PD)液中添加葛根素对PD患者腹腔局部及全身氧化应激状态的影响。方法:38例终末期肾病连续性非卧床腹膜透析(CAPD)治疗患者,随机分为实验组和对照组,每组19例。实验组在PD液中添加葛根素注射液(50mg/2 L),对照组PD液中不加药,均行标准CAPD治疗,每次2 L,4次/d,观察16 d。比较两组患者用药前后血清及透出液氧化应激指标:谷胱甘肽(GSH)、总超氧化物岐化酶(T-SOD)、丙二醛(MDA)以及透析充分性指标的变化。结果:用药后实验组患者血清及透出液GSH、T-SOD均较用药前显著升高(P<0.05),透出液MDA在用药后显著降低(P<0.05),患者血清清蛋白、总肌酐清除率(Ccr)、尿素氮清除指数(K t/V)、每天超滤量无明显变化。结论:在PD液中短期应用葛根素,可改善患者腹腔局部及全身的氧化应激状态。Objective：To investigate the impact of Puerarin on oxidative stress in patients undergoing continuous ambulatory peritoneal dialysis （CAPD）. Methods： Thirty-eight patients CAPD were randomly divided into two groups, an experimental group （n = 19） receiving peritoneal dialysis fluid containing Puerarin （50 mg/2L） in vivo for two weeks and a control group （n = 19） receiving dialysis fluid without Puerarin. The concentrations of oxidative stress markers in the serum and effluent such as glutathione （ GSH）, total-superoxide dismutase （ T-SOD ）, malondialdehyde （ MDA）, Kt/V and creatinine clearance rate of the two groups （Ccr） were measured and compared before and after the treatment. Results ： After the treatment, the concentrations of GSH and T-SOD in the serum and effluent were significantly higher （P 〈 0.05 ） and that of MDA in the effluent was significantly lower in the experimental group than before the treatment （P 〈 0.05 ）. No significant difference was found in the serum albumin, Kt/V, the volume of ultrafihration and Ccr. Conclusion： Short-term supplementation of Puerarin to peritoneal dialysis fluid can ameliorate oxidative stress in patients on CAPD without apparent side effects.

关 键 词：葛根素 腹膜透析 氧化应激 

分 类 号：R692.5[医药卫生—泌尿科学]