救心胶囊对缺氧损伤内皮细胞6-keto-PGF_(1α)、TXB_2释放的影响  

EFFECT OF JIUXIN CAPSULE TO VASOMOTOR CYTOKINE EXPRESSION OF ENDOTHELIAL CELL AFTER HYPOXIA

作　　者：卢斌[1] 杨琳[1] 范英昌[1] 

机构地区：[1]天津中医药大学实验教学部,天津300193

出　　处：《九江医学》2007年第3期10-12,共3页Jiujiang Medical Journal

基　　金：天津市卫生局中医;中西医结合项目(0242)

摘　　要：目的:通过观察救心胶囊对损伤内皮细胞舒缩因子释放的影响,探讨该药防治冠心病的作用机制。方法:建立缺氧损伤内皮细胞模型,用两种不同的给药方式(即无菌中药提取液和载药血清)处理以上模型,运用放射免疫的方法检测6-酮-前列腺素(6-keto-PGF1α)、血栓素B2(TXB2)的表达。结果:内皮细胞损伤后舒张因子水平降低而收缩因子表达明显增加,救心胶囊可以改善血管舒缩因子的失衡状态。结论:救心胶囊通过保护内皮细胞,维持血管的正常舒缩状态,从而延缓冠心病的发生发展。OBJECTIVE ： By observing the influence of Jiuxin capsule on vasomotor cytokine expression of endothelial cell （EC） after being injured by hypoxia , to explore the mechanism of Jiuxin capsule on CHD. METHOD： The cell injury model was established by hypoxia and the drugs - sterilized pure extract of serum containing Jiuxiu capsule was added , then the expression of TXB2, PGF1α with radio immunochemical method and biochemical method were analyzed respectively. RESULTS ： The results showed the stretch cytokine expression of EC after being treated by hypoxia decreased , however shrink cytokine expression increased , Jiuxin capsule can improve the unbalance state. CONCLUSION ： By protecting EC and maintaining normal vasomotor state , Jiuxin capsule can effectively prevent the formation and progress of CHD.

关 键 词：救心胶囊 内皮细胞 6-酮-前列腺素 血栓素B2 

分 类 号：R97[医药卫生—药品]