菌蚀型功能材料的合成与生物降解  

Synthesis and biodegradation of the bacterial-erodible functional materials

作　　者：陈建海[1] 陈清元[1] 沈家瑞[2] 

机构地区：[1]南方医科大学南方医院药学部,广东广州510515 [2]华南理工大学高分子材料系,广东广州510640

出　　处：《功能材料》2007年第3期427-431,共5页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(39970876)

摘　　要：设计与合成一种菌蚀型功能材料,探讨在模拟结肠环境下,材料降解性能与化学结构关系。用对甲基丙烯酰胺偶氮苯(BMAAB)为偶联剂,以偶氮二异丁腈(AIBN)为引发剂,以甲基丙烯酸羟乙酯(HE-MA)、甲基丙烯酸甲酯(MMA)、甲基丙烯酸(MAA)为共单体,合成聚甲基丙烯酸羟乙酯-甲基丙烯酸-甲基丙烯酸甲酯[P(HEMA-MAA-MMA)]无规偶氮聚合物。用紫外、红外、核磁共振手段进行化学结构测定。测定该材料溶胀性能,建立体外厌氧条件下模拟结肠环境模型,用GPC凝胶色谱法、DSC差热分析法与SEM扫描电镜法。比较聚合物降解前后分子量、热性能与形态变化。试验结果表明,材料溶胀指数Q随材料中HEMA-MAA含量增加而增大。材料在模拟结构内容液环境中,降解程度与材料中亲水组分含量直接相关。该材料具有菌蚀功能,有望作为结肠靶向给药系统载体。To design and synthesize a erodible functional materials as the vector for colon-site specific drug delivery and investigate the relationship between the biodegradation properties and composition of materials in the simulated colon fluid. The azo-polymer P（MEMA-MAA-MMA） was synthesized using 2-hydroxyethylmethacrylate （HEMA）,methacrylic acid （MAA）, methyl methacrylate （MMA） as co-monomer,azobisisobutyronitrilel （AIBN） as initiator and cross-linked with bis （methacryloylamino）-azobenzene （BMAAB）. The chemical structure of the synthesized series of azo-copolymer is examined in the light of UV,FTIR spectroscopy results and nuclear magnetic resonance data. Their swelling behavior is evaluated by the swelling equilibrium parameter Q, the biodegradation tests of the materials are carried out at physiologically relevant buffer designed to mimic the colon environment. The biodegradation properties are assessed using the differential scanning calorimeters （DSC） and gel permeation chromatography （GPC） and the morphology on the surface of materials before and after degradation was observed by scanning electron microscopy （SEM）. The test shows that the swelling equilibrium parameter Q increased with increasing the contents of HEMA and MAA in the materials. The degradation behavior was relevant to the ratio of three components in the copolymers. It was proved that this materials could become a good carrier for the colon-site specific drug delivery system if the contents of co-monomer HEMA,MMA and MAA are adjusted reasonably.

关 键 词：结肠靶向系统 偶氮聚合物 溶胀性能 生物降解 

分 类 号：R943.42[医药卫生—药剂学] R945.2[医药卫生—药学]