改性氧化石墨/聚合物的制备及其体外抗凝血性能的评价  

Synthesis of polymer/modified graphite oxide biomaterials and in vitro antithrombogenicity assessment

作　　者：陈亚红[1] 周宁琳[1] 孟娜[1] 黄颖霞[1] 高南萧[1] 李利[1] 章峻[1] 魏少华[1] 沈健[1] 

机构地区：[1]南京师范大学化学与环境科学学院

出　　处：《功能材料》2007年第3期438-440,445,共4页Journal of Functional Materials

基　　金：科技部重大基础研究前期研究专项资助项目(2005CCA00400);教育部博士点基金资助项目(20050319010);江苏省教育厅基金资助项目(04KJB430072;JH03-013;JHjd03-008);江苏省发改委资助项目(苏发改高技发2004419)

摘　　要：利用溶液插层法合成了新型的硅橡胶/氧化石墨-十八烷基二甲基-2-羟乙基溴化铵-肝素纳米抗凝血复合膜材料,并通过机械性能测试、X射线衍射、血小板黏附试验和肝素扩散速率测定实验对复合膜材料的力学性能和血液相容性进行了表征。结果表明,这种新型的抗凝血生物材料具有良好的力学性能和优良的血液相容性,并且肝素扩散缓慢,具有相对长效的抗凝血活性,可望在生物医学工程方面得到广泛的应用。A novel anticoagulative biomaterial which was prepared from modified graphite oxide and silicone rubber through solution intercalated reaction was synthesized. The excellent properties of the new type nanocomposites, such as good mechanical strength and blood compatibility, have been characterized by XRD, mechanical properties,adhesion of blood platelet test and the heparin release rate test. The results demonstrate that the nanocomposites are improved not only in mechanical properties and biocompatibility, but also in the long-time blood compatibility, which could be expected to find wide application in the medical treatment in future.

关 键 词：改性氧化石墨 硅橡胶 纳米复合材料 机械性能 血液相容性 

分 类 号：O613.71[理学—无机化学]