蛋白质转导结构域的跨血脑屏障药物递送  

Drug delivery to the brain using PTD transport systems

作　　者：周建平[1] 孙曼霁[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国药理学通报》2007年第11期1401-1405,共5页Chinese Pharmacological Bulletin

基　　金：军队十一.五科技攻关资助项目(No06G119)

摘　　要：药物递送入脑的主要障碍是血脑屏障,为克服血脑屏障,目前主要采取神经外科手术、增加分子脂溶性、通过内源性血脑屏障转运载体的递送策略。PTD介导跨血脑屏障药物递送是近来出现的新技术,可以方便、高效地使各种分子通过外周血、腹腔等途径,跨越血脑屏障进入脊髓、脑组织细胞。PTD递送快捷、简单、安全,为中枢神经系统疾病的治疗提供了新的研究思路。Blood brain barrier is the main obstacle for drug delivery to the brain. To overcome the limited access of drugs to the brain, three methods have been developed at present：neurosurgical-based strategies, chemistry-based strategies to increase the lipid solubility of the drug, and biology-based strategies of endogenous BBB transporters-mediated drug delivery. PTD transport system to delivery drug across BBB is an emerging technology,which conveniently and efficiently deliver various molecules into spinal cord and brain via blood ,intraperitoneally etc. PTD transport system offers a new approach to central nervous system disease with quick, convenient and safe charcteristics.

关 键 词：蛋白质转导结构域 血脑屏障 药物递送 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学] R341[医药卫生—基础医学]