抗氧化效应法研究葛根黄酮微丸的药动学  

Pharmacokinetics of pueraria flavonoids from Pueraria lobata by anti-oxidant pharmacodynamics effect method

作　　者：贾晓斌[1] 蔡垠[1] 陈彦[1] 成旭东[1] 范晨怡[1] 施亚芳[1] 

机构地区：[1]江苏省中医药研究院江苏省现代中药制剂工程技术研究中心

出　　处：《中国中药杂志》2007年第22期2370-2373,共4页China Journal of Chinese Materia Medica

基　　金：江苏省中医药管理局科学技术研究专项(ZY0304);江苏省卫生厅"135工程"重点人才项目(65RC2002065)

摘　　要：目的:研究葛根黄酮微丸的药动学。方法:采用抗氧化效应法测定给药后不同时间点大鼠血浆中所含黄酮类成分的抗氧化能力,计算出血浆中黄酮类物质的含量,得到大鼠给药葛根黄酮后血浆中黄酮类物质的含量的变化曲线,得出微丸制剂在体内的药动学过程。结果:葛根黄酮微丸给药后的AUC为愈风宁心片的4.40倍。结论:将葛根黄酮制成微丸能够有效提高葛根中黄酮类物质的生物利用度。Objective： To study the pharmacokinetics of pueraria flavonoids （PF） from Pueraria lobata. Method： An anti-oxidant pharmacodynamics effect method was quoted to detect the antioxidant ability of PF contained in rats plasm after oral delivered, measures the fluorescence intensity, and calculates the concentration of components in plasma, then we can get the plot of the change of the content of PF contained in rats plasm, and then we can get the pharmacokinetics of Pueraria Flavonoids pellets. Result： The AUC of Pueraria lobata isoflavone pellets is 4.40-fold of Yufengningxin tablets. Conclusion： It can enhance the bioavailability of PF by made it to pellets.

关 键 词：抗氧化效应法 葛根素 葛根黄酮 微丸 愈风宁心片 

分 类 号：R285[医药卫生—中药学]