阻塞性睡眠呼吸暂停低通气综合征患者术后血脂变化的研究  

Changes of blood lipid in patients with obstructive sleep apnea hypopnea syndrome before and after surgical treatment

作　　者：韦升利[1] 李金霞[1] 刘吉祥[1] 刘鸿源[1] 艾建伟[1] 

机构地区：[1]天津市人民医院耳鼻喉科-鼾症诊疗中心,天津300121

出　　处：《中国耳鼻咽喉颅底外科杂志》2007年第5期360-362,共3页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OS-AHS)患者接受悬雍垂腭咽成形术(uvulopalatopharyngoplasty,UPPP)治疗前后血脂的变化。方法选取42例OSAHS患者组和40例正常对照组,均经多导睡眠监测(PSG)检查,并空腹抽取静脉血测定血脂水平。将两组血脂中的总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白-A(Apo-A)和载脂蛋白-B(Apo-B)进行比较。并对42例OSAHS患者行悬雍垂腭咽成形术(UPPP),术后6个月的相应检查指标与术前作比较。结果术前OSAHS组患者血中TG、TC、LDL、Apo-B高于对照组;Apo-A低于对照组,HDL有低于对照组趋势,但差异均无统计学意义,42例OSAHS患者经UPPP治疗6个月后,TG、TC、LDL、Apo-B及AHI与术前比较显著降低,Apo-A和HDL升高。结论OSAHS可引起脂代谢异常,行UPPP治疗有助于纠正OSAHS患者的脂代谢紊乱。Objective To investigate the influence of uvulopalatopharyngoplasty （UPPP） on blood lipid in obstructive sleep apnea hypopnea syndrome （OSAHS） patients. Methods Forty-two OSAHS patients and forty normal volunteers were evaluated with polysomnography during sleep. Serum total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL）, low density lipoprotein （LDL）, apoA, and apoB were measured. All the OSAHS patients were treated by UPPP, and their blood lipid indices were detected after operation. Results The levels of TG.TC.LDL, and Apo-B in OSAHS patients were significantly higher than those in the control group. The level of apo-A of severe OSAHS patients was significantly lower than that of the controls. The level of HDL of OSAHS patients was lower than that of the controls, but the difference was insignificant. The levels of TG.TC. LDL. Apo-B, and AHI were significantly reduced six months after UPPP. Conclusion The abnormal lipid metabolism may be caused by OSAHS, and the abnormalities can be reversed by UPPP.

关 键 词：睡眠呼吸暂停 阻塞性 悬雍垂腭咽成形术 血脂 

分 类 号：R563.8[医药卫生—呼吸系统]