人神经干细胞移植治疗重度新生儿一氧化碳中毒一例  

Case report of a neonate with severe carbon monoxide poisoning treated with transplantation of human neural stem cells

作　　者：屈素清[1] 栾佐[1] 尹国才[1] 刘卫鹏[1] 胡晓红[1] 龚小军[1] 

机构地区：[1]北京海军总医院儿科,100037

出　　处：《中国新生儿科杂志》2007年第6期334-336,共3页Chinese Journal of Neonatology

摘　　要：目的探讨人神经干细胞移植治疗新生儿重度一氧化碳中毒(COP)的可行性。方法1例生后18d的新生儿重度COP急性期患儿,肌张力异常,原始反射减弱,NBNA评分15分。取孕12周胚胎前脑细胞体外培养扩增11d,获取人神经干细胞(NSCs)球,经患儿脑室穿刺注入。结果移植后28d,患儿肌张力、原始反射明显改善,NBNA评分35分。移植后9个月Peabody量表,0～6岁儿童神经心理检查量表评估,患儿运动、智力、语言发育正常。结论本例人胚胎来源NSCs移植治疗急性期新生儿重度COP,临床疗效显著。最终的疗效还需更多病例的进一步观察。Objective To evaluate the treatment of human neural stem cells （NSCs） transplantation for acute severe carbon monoxide poisoning （COP） in one newborn infant. Methods The patient was an 18-day infant in acute stage of severe COP presented with increased muscle tone , decreased new- born reflexes and very low Neonatal behavioral neorological assessment （NBNA） score（only 15）. The NSCs were obtained from the proencephalon of a 12 weeks old fetus, the ceils were cultured and proliferated for 11 days and then were injected into cerebral ventricle of this patient. Results 28 days after transplantation, the infant showed significant improvement of muscle tones and primitive reflexes and NBNA score increased to 35. Nine months after transplantation, the infant was evaluated by Peabody development motor scale and 0 -6 year＇s old children Neuro-psychology development scale and showed normal movement, intelligence and speech compared with children of the same age. Conclusions Human NSCs transplantation into cerebral ventricle in acute conclusion needs further study. severe COP improves the outcome of this baby. Definite conclusion needs further study.

关 键 词：干细胞移植 一氧化碳中毒 婴儿 新生 

分 类 号：R722.1[医药卫生—儿科]