制菌霉素与固体支撑磷脂膜的相互作用  

Investigation of the Interaction Between Nystatin and Solid-supported Phospholipid Membranes

作　　者：王青[1] 羊小海[1] 汪红[1] 王柯敏[1] 

机构地区：[1]湖南大学化学生物传感与计量学国家重点实验室

出　　处：《高等学校化学学报》2007年第11期2078-2080,共3页Chemical Journal of Chinese Universities

基　　金：国家'九七三'计划项目(批准号:2002CB513110);国家科技攻关计划(批准号:2005EP090026);国家自然科学基金重点项目(批准号:90606003);国家自然科学基金(批准号:20475015);湖南大学校基金资助

摘　　要：Nystatin is a polyene antifurgal drug to which many molds and yeasts are sersitive, including cryptococcus neoformans, candida, aspergillus, etc. To realize the mechanism of nystatin more particularly, the techniques of SPR and impedance were used to investigate the interaction between nystatin and two kinds of solid-supported phospholipid membranes. The results show that nystatin could interact with pure phospholipid membranes, whether they are monolayer or bilayer. In addition, impedance spectra show that ion channels may be formed when nystatin interacted with phospholipid membranes.Nystatin is a polyene antifurgal drug to which many molds and yeasts are sersitive, including cryptococcus neoformans, candida, aspergillus, etc. To realize the mechanism of nystatin more particularly, the techniques of SPR and impedance were used to investigate the interaction between nystatin and two kinds of solid-supported phospholipid membranes. The results show that nystatin could interact with pure phospholipid membranes, whether they are monolayer or bilayer. In addition, impedance spectra show that ion channels may be formed when nystatin interacted with phospholipid membranes.

关 键 词：表面等离子体共振 交流阻抗 固体支撑磷脂膜 制菌霉素 

分 类 号：O657.39[理学—分析化学]