14株医院感染病原菌对对氯间二甲苯酚抗力的观察  

OBSERVATION ON RESISTANCE OF 14 STRAINS OF NOSOCOMIAL INFECTION PATHOGENS TO P-CHLORO-M-XYLENOL

作　　者：谈智[1] 陈越英[1] 徐燕[1] 吴晓松[1] 沈元 戎毅[1] 王晓蕾[1] 

机构地区：[1]江苏省疾病预防控制中心,南京210009 [2]无锡市疾控中心

出　　处：《中国消毒学杂志》2007年第6期496-498,共3页Chinese Journal of Disinfection

基　　金：江苏省现代病原生物学重点实验室开放课题;江苏省疾病预防控制中心青年科研基金立项指导项目(JSQZ200507)资助

摘　　要：目的了解常见医院感染病原菌对对氯间二甲苯酚的抗力。方法肉汤稀释法对14株医院感染病原菌进行最低抑菌浓度和最小杀菌浓度测定。结果对氯间二甲苯酚对7株临床分离的铜绿假单胞菌的最小抑菌浓度范围为78 mg/L^625 mg/L,WX11株最高,WX44株与WX12株最低;另外4株与标准株的M IC均为312 mg/L。对氯间二甲苯酚对7株临床分离的铜绿假单胞菌的最小杀菌浓度范围为156~1250 mg/L,WX45株与NJ90株MBC最高,WX12与WX44最低;其余3株与标准株的MBC均为625 mg/L。对氯间二甲苯酚对7株临床分离的大肠杆菌的M IC和MBC均与标准菌株一致。结论铜绿假单胞菌对对氯间二甲苯酚抗力有差异,存在抗力株和敏感株;大肠杆菌对对氯间二甲苯酚抗力与标准株相同。Objectives To know the resistance of common nosocomial infection pathogens to P - chloro - m - xylenol （PCMX） . Method The minimal inhibiting concentration （MIC） and minimal bactericidal concentration （MBC） of PC- MX for 14 strains of the nosocomial infection pathogens were determined using broth dilution method. Results The MICs for the different strains of Pseudomonas aerugionosa were 78 - 625 mg/L and the MIC for Escherichia coli was 156mg/L. The MBCs for different strains for Pseudomonas aeruginosa were 156 - 1250 mg/L and the MBC for Escherichia coli was 156 mg/L. Condusion The resistance of the different strains of Pseudomonas aerugionosa to PCMX was different , there were resistant strains and sensitive strains, while the resistance of different strains of Escherichia coli was not different.

关 键 词：对氯间二甲苯酚 铜绿假单胞菌 大肠杆菌 抗性 

分 类 号：R187.2[医药卫生—流行病学]