定量组织速度成像技术评价大鼠冠脉微血栓栓塞后左室收缩功能  

Evaluation of left ventricular systolic function after coronary artery microthrombosis in rats using quantitative tissue velocity imaging

作　　者：王曼[1] 谢明星[1] 王朝晖[2] 吴婕[2] 谢建[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院超声影像科,湖北武汉430022 [2]华中科技大学同济医学院附属协和医院心内科,湖北武汉430022

出　　处：《中国医学影像技术》2007年第10期1433-1436,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的应用定量组织速度成像结合二维超声心动图观察冠脉微血栓栓塞对大鼠左室形态及收缩功能的影响。方法24只SD大鼠随机分为两组:冠脉微血栓组12只,自主动脉根部注入月桂酸钠诱发冠脉微血栓形成;对照组12例,自主动脉根部注入生理盐水。术前及手术4周后行超声心动图检查,测量左室舒张末期内径(LVEDD)、收缩末期内径(LVESD)、左室舒张末期容积(EDV)、左室射血分数(LVEF),计算左室短轴缩短率(FS),术后加用QTVI测量收缩期峰值。结果与对照组相比,微血栓组LVESD、LVEDD、EDV显著增加(P<0.01);FS、LVEF显著降低(P<0.01);微血栓组心尖四腔左室侧壁及后间隔二尖瓣环、左室长轴观前间隔及后壁中间段收缩期峰值速度显著下降(P<0.01)。结论大鼠慢性冠脉微血栓栓塞后,心室发生重塑,收缩功能下降。定量组织速度成像结合二维超声心动图能较准确评价大鼠冠脉微血栓栓塞后的左室收缩功能的改变。Objective To evaluate the change of left ventricular remodeling shape and systolic function following coronary artery microthrombosis （CAM） in rats using quantitative tissue velocity imaging and two-dimensional echocardiography. Methods Twenty-four SD rats were divided into CAM group （n=12） and control group （n=12）. Sodium laurate was injected into aorta root of CAM group during clamping the ascending aorta to create a model of CAM while the normal sodium was injected to the control group. A serial echocardiography was performed to monitor the alterations of cardiac function. Four weeks after coronary artery microthombosis, quantitative tissue velocity imaging was performed in each group. Results When compared with control group, the left ventricular end-systolic diameter and end-diastolic diameter and left ventricular end-diastolic volume in the CAM group were significantly increased （P〈0.01）. The parameters of left ventricular systolic function and ejection fraction were all significantly decreased （P〈0.01）. The peak systolic velocity at mitral annulus on apical 4-chamber view, the middle segment of the anterior interventricular septum and left ventricular posterior wall on parasternal long axis view were also significantly decreased. Conclusion Using quantitative tissue velocity imaging combined with two-dimensional echocardiography, we can assess left ventricular remodeling and systolic function after coronary artery microthombosis comprehendsively, quantitatively and noninvasively.

关 键 词：超声心动描记术 定量组织速度成像 冠脉微血栓 大鼠 左室重构 收缩功能 

分 类 号：R445.1[医药卫生—影像医学与核医学] R543.31[医药卫生—诊断学]