醛糖还原酶抑制剂和肌醇对糖尿病视网膜组织中糖及糖醇含量的影响  

INFLUENCE OF ALDOSE REDUCTASE INHIBITOR OR MYO INOSITOL ON CONTENTS OF GLUCOSE,SORBITOL AND MYO INOSITOL OF DIABETIC RETINAL TISSUE IN RAT

作　　者：刘谊[1] 罗成仁[1] 梁茂植[1] 秦勇平 余勤[1] 

机构地区：[1]华西医科大学附属第一医院眼科

出　　处：《中华眼底病杂志》1997年第2期75-77,共3页Chinese Journal of Ocular Fundus Diseases

基　　金：国家自然科学基金;国家教委博士点专项科研基金

摘　　要：目的：研究醛糖还原酶抑制剂及肌醇管饲对实验性糖尿病视网膜组织中葡萄糖、山梨醇和肌醇含量的影响。方法：给链脲佐菌素诱发的糖尿病大鼠饲以醛糖还原酶抑制剂或肌醇，于实验６月末用高效液相色谱法分析各组视网膜组织中葡萄糖、山梨醇和肌醇的含量。结果：糖尿病组葡萄糖、山梨醇含量显著增高，肌醇含量明显下降；糖尿病＋醛糖还原酶抑制剂组山梨醇含量明显低于糖尿病＋肌醇组和糖尿病组，而肌醇含量未见减少；糖尿病＋肌醇组肌醇含量与正常对照组无显著差异，但山梨醇水平仍然升高。结论：醛糖还原酶抑制剂能有效地阻止视网膜组织中山梨醇聚集和肌醇含量下降；肌醇对组织中山梨醇的含量无影响，但能提高肌醇浓度。PURPOSE:To investigate the influence of orally administered aldose reductace inhibitor(ARI) and myo inositol(MI)for contents of glucose,sorbitol and myo inositol in experimental diabetic retinal tissue in rat.METHODS:The STZ induced diabetic rats were administered ARI or MI by oral.The glucose,sorbitol and myo inositol in retinal tissues were analysed by high performance liquid chromatography after experimental period of 6 months. RESULTS:It was found that the contents of glucose and sorbitol were increased and myo inositol was decreased in diabetic group.In diabetes with ARI group,the content of sorbitol was decreased although the glucose was in high level.In diabetes with MI group,the sorbitol accumulated and content of myo inositol was close to the normal control group. CONCLUSIONS:The ARI can effectively obstruct sorbitol accumulation in retina. MI increase myo inositol level but fail to reduce sorbitol content of retina.

关 键 词：糖尿病 视网膜疾病 醛糖还原酶 ARI 肌醇 

分 类 号：R587.105[医药卫生—内分泌] R774.105[医药卫生—内科学]