补骨脂生品、老品及新品的药效和毒性比较  

Comparative Studies on Pharmacological and Toxic Actions of Raw Fructus Psoraleae and Its Salt baked and Improved Salt baked Products

作　　者：姚祥珍[1] 沈鸿[1] 吴子伦[1] 张玉顺[1] 回连强[1] 富杭育[1] 

机构地区：[1]中国中医研究院中药研究所

出　　处：《中国中药杂志》1997年第6期341-343,共3页China Journal of Chinese Materia Medica

基　　金：国家"八五"重点科技攻关项目

摘　　要：对补骨脂盐炙新法制品同老法制品作了药效和毒性的比较研究。新法制品的升白作用优于老法制品；在止泻和对性器官重量的影响上，两者无显著差异。新法制品灌胃ＬＤ５０及对肾组织的损伤等毒性上则小于老法制品。结果提示本工艺改进有助于增效、减毒。The pharmacological and toxic actions of raw Fructus Psoraleae and its salt baked, and improved salt baked products were comparatively studied. The leucogenic action of the improved salt baked product was more effective than that of the original salt baked one. But no significant difference in antidiarrheal or antiandrogenoid effect was found betwean the two salt baked products. The toxicity(LD 50 and the injury on kidney )of the improved salt baked product was lower than that of the salt baked. one. The results indicate that this improved processing method would contribute to increasing the efficacy and decreasing the toxicity of Fructus Psoraleae.

关 键 词：补骨脂 炮制工艺 药效 毒性 

分 类 号：R285.5[医药卫生—中药学] R282.710.5[医药卫生—中医学]