Ca^2＋调控的胰岛素分泌  

Calcium-regulated insulin secretion

作　　者：田登梅[1] 焦凯[1] 

机构地区：[1]第四军医大学唐都医院内分,西安710038

出　　处：《国际内分泌代谢杂志》2007年第6期383-385,共3页International Journal of Endocrinology and Metabolism

基　　金：陕西省科技攻关课题[2004k16-G2（2）]

摘　　要：胰岛β细胞内胰岛素分泌颗粒胞裂外排，从而分泌胰岛素。该过程是由胰岛素分泌颗粒局部Ca^2＋浓度的迅速升高而触发的。胰岛β细胞内Ca^2＋浓度的迅速升高主要源于经质膜上钙通道的Ca^2＋内流和胞内钙库Ca^2＋释放。细胞外钙内流主要通过电压依赖型钙通道，而胞内Ca^2＋释放可能来自三磷酸肌醇敏感钙库、尼克酰胺腺嘌呤二核苷酸磷酸（NAADP）敏感钙库、ryanodine敏感钙库及线粒体钙库等。不同情况下的胰岛素分泌或胰岛素分泌的不同阶段可能由不同来源的Ca^2＋触发或增强，两者相互协调，在胰岛素分泌中起重要作用。因此，对β细胞内钙信号的产生及调控途径的深入研究有利于进一步阐明糖尿病的发病机制，并为糖尿病的治疗提供新思路。A rapid rise in the localized Ca^2＋ concentration from secretory granules due to influx of extraeellular Ca^2＋ or mobilization from intracellular stores is the primary trigger for exocytosis to secrete insulin in pancreatic β cells. Extracellular Ca^2＋ mostly inflows through voltage-operated Ca^2＋ channels on plasma membrane, and intracellular Ca^2＋ store release probably comes from IP3-sensitive Ca^2＋ stores, NAADP-sensi- rive Ca^2＋ stores,ryanodine-sensitive Ca^2＋ stores, mitochondrial Ca^2＋ stores, and so on. Different states or phases of insulin secretion are triggered or strengthened by distinct Ca^2＋ sources, which intercoordinate and play the important role in insulin secretion. Thus, the further investigation of production and regulation of intracellular Ca^2＋ signal will be better to illuminate the pathogenesis of diabetes in order to provide new ideas for therapy of diabetes.

关 键 词：胰岛素分泌 胞内钙离子 胰岛B细胞 

分 类 号：R587[医药卫生—内分泌]