The synthesis and cytotoxic activity of novel organogermanium sesquioxides with anthraquinone or naphthalene moiety  

作　　者：Guo Qiang Shangguan Lun Liang Huang Xiao Gang Qu 

机构地区：[1]Department of Pharmacy, Jining Medical College, Rizhao 276826, China [2]Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

出　　处：《Chinese Chemical Letters》2007年第11期1347-1350,共4页中国化学快报（英文版）

摘　　要：Four novel organogermanium scsquioxidcs with anthraquinonc or naphthalene moiety were synthesized. The structures were characterized by IR NMR and elemental analysis, and their cytotoxicitics wcrc evaluated against human chronic mycloid leukemia K562 cell lines. The cytotoxicity could bc improved by the introduction of planar aromatic chromophorc moiety to the parent compound, Ge-132.Four novel organogermanium scsquioxidcs with anthraquinonc or naphthalene moiety were synthesized. The structures were characterized by IR NMR and elemental analysis, and their cytotoxicitics wcrc evaluated against human chronic mycloid leukemia K562 cell lines. The cytotoxicity could bc improved by the introduction of planar aromatic chromophorc moiety to the parent compound, Ge-132.

关 键 词：Organogermanium sesquioxide SYNTHESIS Cytotoxicity 

分 类 号：O62[理学—有机化学]