Antioxidant activity of bovine serum albumin binding amino acid Schiff-bases metal complexes  

作　　者：Rong Min Wang Juan Juan Mao Jing Feng Song Cai Xia Huo Yu Feng He 

机构地区：[1]Key Laboratory of Polymer Materials of Gansu Province, Institute of Polymer, Northwest Normal University, Lanzhou 730070, China

出　　处：《Chinese Chemical Letters》2007年第11期1416-1418,共3页中国化学快报（英文版）

摘　　要：Glutamic acid-salicylaldehyde Schiff-base metal complexes are bound into bovine serum albumin （BSA）, which afforded BSA binding Schiff-base metal complexes （BSA-SalGluM, M=Cu, Co, Ni, Zn）. The BSA binding metal complexes were characterized by UV-vis spectra and Native PAGE. It showed that the protein structures of BSA kept after coordinating amino acid Schiff-bases metal complexes. The effect of the antioxidant activity was investigated. The results indicate that the antioxidant capacity of BSA increased more than 10 times after binding Schiff-base metal complexes.Glutamic acid-salicylaldehyde Schiff-base metal complexes are bound into bovine serum albumin （BSA）, which afforded BSA binding Schiff-base metal complexes （BSA-SalGluM, M=Cu, Co, Ni, Zn）. The BSA binding metal complexes were characterized by UV-vis spectra and Native PAGE. It showed that the protein structures of BSA kept after coordinating amino acid Schiff-bases metal complexes. The effect of the antioxidant activity was investigated. The results indicate that the antioxidant capacity of BSA increased more than 10 times after binding Schiff-base metal complexes.

关 键 词：Natural polymer Schiff-base metal complexes Glutamic acid Bovine serum albumin （BSA） ANTIOXIDANTS Hydroxyl radicals 

分 类 号：O6[理学—化学]