CETP基因TaqIB及I405V多态性与新疆维吾尔族自然长寿的关联  

The Correlation of the Polymorphisms of CETP Gene with the Natural Longevity in Uygur Population

作　　者：孙凌[1] 许群[2] 程祖亨[1] 邱长春[2] 

机构地区：[1]新疆医科大学,乌鲁木齐830054 [2]中国医学科学院基础医学研究所医学分子生物学国家重点实验室,北京100005

出　　处：《医学研究杂志》2007年第11期27-30,共4页Journal of Medical Research

基　　金：国家自然科学基金资助(批准号:30160089)

摘　　要：目的探讨胆固醇酯转运蛋白(CETP)基因TaqIB及I4O5V多态性与维吾尔族自然长寿之间的关系。方法以新疆和田地区191名90岁以上的维吾尔族自然长寿个体为研究对象,以53名在75岁前自然死亡的同地区、同民族相匹配个体作为对照。采用PCR-限制长度片段多态性(PCR-RFLP)和PCR-直接测序法(PCR-Sequencing)对CETP基因TaqIB及I4O5V多态性进行分型。结果CETP基因TaqIB及I4O5V多态性基因型、等位基因分布在长寿组和对照组之间无差异。结论CETP基因TaqIB及I405V多态性与新疆维吾尔族自然长寿无关。Objective To investigate the relation ship between two polymorphisms within the CETP gene, TaqlB and I405V, and natural longevity in the Uygur population. Methods 191 healthy individuals over 90 years old and 53 control individuals who died before their 75 years were recruited. The polymorphisms within CETP gene, TaqlB and I405V, were genotyped by PCR - RFLP and PCR - Sequencing. Results There were no difference in the genotypes and alleles distribution of two polymorphisms within the CETP gene between longevity group and control group. Conclusions There was no correlation between the polymorphisms within CETP gene, TaqIB and I405V, and natural longevity of Uygur population in Hetian.

关 键 词：CETP 多态性 长寿 维吾尔族 

分 类 号：R816.1[医药卫生—放射医学]