E-选择素+G98T,+A561C基因多态性与原发性高血压及左室重构的关系  

Association of E-selectin +G98T,+A561C gene polymorphisms and left ventricle reconstitution in patients with essential hypertension

作　　者：宋芸[1] 林岫芳[1] 王东伟[1] 董丹丹[1] 

机构地区：[1]中山大学附属第五医院心内1科,广东珠海519000

出　　处：《第四军医大学学报》2007年第22期2075-2078,共4页Journal of the Fourth Military Medical University

基　　金：珠海市科技局资助(PC20061071)

摘　　要：目的:探讨E-选择素(E-selectin)+G98T,+A561C基因多态性与原发性高血压及左室重构的关系.方法:对105例原发性高血压患者(高血压组)及94健康正常人(对照组)进行E-selectin+G98T,+A561C基因多态性检测及超声心动图、血脂水平检测.结果:①E-selectin+A561C各基因型在原发性高血压组和对照组间的分布差异存在统计学意义(P<0.05);②E-selectin+G98T基因型在原发性高血压组和对照组间的分布差异无统计学意义(P>0.05);等位基因频率在两组中分布差异亦无统计学意义(P>0.05);③原发性高血压组内,AC-CC基因型更倾向于发生左室肥厚(P<0.05);④原发性高血压组和对照组E-selectin+G98T位点及+A561C位点各基因型组间血脂水平比较差异均无统计学意义(P>0.05).结论:E-selectin+A561C位点单核苷酸多态性与原发性高血压具有相关关系,C等位基因可能是原发性高血压发病的遗传易感基因.C等位基因原发性高血压患者更倾向于出现左室重构.AM： To study the relationship between E-selectin gene polymorphisms and left ventricle reeonstitution in patients with essential hypertension. METHODS： Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method was used to determine ＋ G98T and ＋ A561C locus mutation polymorphisms in E-seletin gene in patients with essential hypertension and controls. Automated Biochemical Analyzer was used to measure the serum lipids. RESULTS. （1） There was significant difference in frequencies of genotype in E-selectin ＋ A561C polymorphism between the essential hypertension group and the control group （ P 〈 0.05 ）. （2） There was no significant difference in distribution of the E-selectin gene ＋ G98T genotype between the essential hypertension group and the control group （P 〉 0. 05 ）. （3） In essential hypertension group, AC-CC genotype was prone to suffer the left ventricle reeonstitution （ P 〈 0. 05 ）. （4） There was no significant difference in the levels of serum lipids for different genotypes of ＋ G98T or ＋ A561C locus between the essential hypertension group and the control group. CONCLUSION： E-selectin gene ＋ A561C polymorphism is associated with essential hypertension. C allele may be a risk factor for essential hypertension, and essential hypertension patients with C allelt are prone to suffer left ventricle reeonstitution.

关 键 词：E-选择素 高血压 多态现象 遗传 心室重构 

分 类 号：R544.1[医药卫生—心血管疾病]