机械刺激与脂质分子对TREK-1通道的调控  

Modulation of mechanical stimulation and lipid molecule to TREK-1

作　　者：刘旭霞[1] 王伟[1] 钮伟真[1] 

机构地区：[1]首都医科大学基础医学院生理学研究室,北京100069

出　　处：《国际病理科学与临床杂志》2007年第5期421-425,共5页Journal of International Pathology and Clinical Medicine

基　　金：国家自然科学基金(30570663);北京市教委资助课题(KM200510025001);北京市自然科学基金(7052012)~~

摘　　要：双孔钾通道是钾通道超家族的一个新的亚型,它介导背景钾电流,在静息膜电位的形成、复极过程和调控细胞兴奋性方面起重要作用。TREK-1通道作为双孔钾通道的一个成员,可被多种物理和化学刺激所激活,其中机械刺激和脂质分子是TREK-1通道的两种最有效的刺激。探讨TREK-1通道的结构、分布、功能及其活动与机械刺激和脂质分子的关系,将有助于了解TREK-1通道的生理和病理生理学意义。Two-pore-potassium channels（K2P）,acting as background potassium channels,form a novel class of K^＋ channels.They play an essential role in setting resting membrane potentials,participating in repolarization process and regulating cell excitability.TREK-1 is a member of K2P channels and responds to a widest variety of physical and chemical stimuli.Among them mechanical stimuli and lipid molecule are two effective ways to activate TREK-1 channels.To explore TREK-1 structure,distribution,function,lipid and mechano-gated mechanisms will help us understand the physiological and pathological significances of TREK-1 channel.

关 键 词：双孔钾通道 TREK-1通道 脂质分子 机械刺激 

分 类 号：Q2[生物学—细胞生物学]