高血压家族遗传因素与心血管病危险因素聚集关系的研究  

Association Between Genetic Factors of Hypertension and the Clustering of Risk Factors of Cardiovascular Diaeases

作　　者：黄成群[1] 周北凡[1] 武阳丰[1] 杨军[1] 李莹[1] 郭敏[1] 贾宣[1] 

机构地区：[1]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院流行病研究室

出　　处：《中国循环杂志》1997年第4期272-276,共5页Chinese Circulation Journal

摘　　要：目的：探讨高血压遗传因素与心血管病危险因素聚集的关系。方法：采用家系调查方法，对比分析高血压家系和对照家系直系亲属的危险因素个体聚集性。共调查高血压家系２５个，含直系亲属１５８例，其中包括高血压患者５４例，血压正常者１０４例；对照家系１５个，含直系亲属６５人。结果：超重（体重指数＞２５ｋｇ／ｍ２），高甘油三酯（甘油三酯＞２．０ｍｍｏｌ／Ｌ），高尿酸血症（男：尿酸＞３７４．９ｍｍｏｌ／Ｌ；女：尿酸＞３１５．４ｍｍｏｌ／Ｌ），高胰岛素血症（胰岛素＞１２．２μｍｏｌ）及低高密度脂蛋白胆固醇（低高密度脂蛋白胆固醇＜０．９１ｍｍｏｌ／Ｌ）５个危险因素中，具有１个以上至５个以上上述危险者的年龄标化百分比在高血压家系明显高于对照家系，将高血压家系中高血压患者剔除后比较，这种规律依然存在。Objective:To explore the relationship of hypertension prone genetic factors to the clustering of risk factors of cardiovascular diseases(CVD). Methods:Forty pedigrees which included 223 direct relatives, 158 individuals(54 hypertensives and 104 normotensives) in hypertensive pedigrees(HF),65 in normotensive pedigrees(NF),were recruited from Shijinshan district,Beijing.Age adjusted percentages of direct relatives with one or more risk factors in HF were compared with those in NF. Results:Among five metabolic risk factors including overweight(BMI≥25 kg/m 2),hypertriglyceridemia(TG>2 0 mmol/L),hyperuricemia(Male/Female:UA>374 9/UA>315 4 mmol/L),hyperinsulinemia(Insulin>12 2 μmol/L) and low high density lipoprotein cholesterol(HDL C<0 91 mmol/L),proportions of subjects with at least one,two,three,four or five risk factors in HF were significantly higher than those in NF,even if hypertensives in HF were excluded. Conclusion: The results supported the hypothesis that hypertension prone genetic factors play an important role in the clustering of CVD risk factors.

关 键 词：高血压 遗传因素 危险因素 心血管病 

分 类 号：R544.102[医药卫生—心血管疾病] R540.2[医药卫生—内科学]