中国黄海柄海鞘的化学成分  

Chemical Studies on Secondary Metabolites from Chinese Ascidian Styela clava

作　　者：李亮[1] 王长云[2] 郭跃伟[1] 

机构地区：[1]中国科学院上海生命科学研究院药物研究所国家新药研究重点实验室,上海201203 [2]中国海洋大学医药学院海洋药物教育部重点实验室,青岛266003

出　　处：《中国天然药物》2007年第6期408-412,共5页

基　　金：国家海洋863计划(No.2006AA609Z412和No.2007AA609Z447);基金委项目(No.20721003;30730108;20572116);中国科学院重点项目(grantKSCX2-YW-R-18)资助课题;并得到教育部科技创新工程重大项目培育资金项目(No.706038);新世纪优秀人才支持计划(No.NCET-05-0600)部分资助~~

摘　　要：目的:对采自中国黄海的柄海鞘(Styela clava)的化学成分进行研究,从中寻找有生物活性的次生代谢产物。方法:用硅胶柱层析和凝胶柱层析对柄海鞘的丙酮提取物进行分离纯化,根据其化学性质,结合现代波谱技术(MS,NMR等),对得到的化合物进行结构鉴定。结果:分离得到3个类胡萝卜素和1个芳香胺类化合物,其结构分别鉴定为mytiloxanthinone(1)、fucoxanthin(2)、all-trans-astaxanthin(3)和naphthalen-2-yl-phenyl-amine(4)。结论:这些化合物均系首次从柄海鞘中分离得到,并首次对化合物mytiloxanthinon(1)和fucoxanthin(2)的1H和13C NMR数据进行了全归属。To study the chemical constituents of the Chinese aseidian Styela clava aiming at searching for new bioactive substances. METHODS： The acetone extract of Styela dava was subjected to repeated silica gel column chromatography affording four pure compounds （1-4）, the structures of which were elucidated on the basis of detailed spectroscopic analysis and comparison with the data re- ported in literature. RESISTS： Four known compounds were isolated and identified as myfiloxanthinone （1）, fucoxanthin （2）, all-trans- astaxanthin （3） and naphthalen-2-yl-phenyl-amine （4）, respectively. CONCLUSION： All the compounds were isolated from the examined sample for the first time. and a complete ^1 H and ^13C MR data assignments of mytiloxanthinone （1） and fucoxanthin （2） was carried out for the first time.

关 键 词：尾索动物 柄海鞘(Styela clava) 类胡萝卜素 芳香胺 

分 类 号：R284[医药卫生—中药学]