扶正口服液对吗啡依赖大鼠血清NO、NOS的影响  

Effect of FZY on NO and NOS in blood serum of morphine-dependent rat

作　　者：杨铮[1] 黄建春[1] 黄仁彬[1] 黎昀[1] 霍志金 

机构地区：[1]广西医科大学药理学教研室,广西南宁530021 [2]邯郸制药有限公司,河北邯郸056005

出　　处：《中国医药导报》2007年第11X期5-6,共2页China Medical Herald

基　　金：广西自然科学基金(桂科基0575066)

摘　　要：目的:观察扶正口服液(以下简称FZY)对吗啡依赖大鼠戒断症状及血清NO和一氧化氮合成酶(NOS)的影响。方法:剂量递增sc吗啡建立14d大鼠吗啡依赖模型,观察FZY对纳洛酮催促大鼠戒断症状的影响,并用分光光度法测定大鼠血清中NO含量和NOS活性。结果:①FZY两个剂量(5.48、10.96g生药/kg)可显著降低吗啡依赖大鼠催促戒断症状分值(P<0.01),且10.96g生药/kg能明显抑制戒断引起的体重下降(P<0.01);②FZY两个剂量(5.48、10.96g生药/kg)可显著降低血清NO含量和NOS活性,效应呈剂量相关性。结论:扶正口服液能缓解吗啡依赖大鼠戒断症状,其机制可能与抑制体内NOS活性,进而下调NO水平有关。Objective： To observe the effect of FZY on withdrawal symptoms, NO concentration and NOS activity in blood serum of morphine-dependent rat. Methods： 14 days morphine-dependent rat model was induced by administration（sc） of morphine at a gradual increasing dosage. The withdrawal symptoms hastened by naloxone were recorded. NO concentration and NOS activity in blood serum was tested by spectrophotometry. Results： （1）The score of withdrawal symptoms was reduced remarkably by FZY （5.48 g/kg and 10.96 g/kg）, and weight lose was controlled by FZY at the dosage of 10.96 g/ kg; （2）High levels of NO and NOS in blood serum were reduced by FZY at the dosage of 5.48 g/kg and 10.96 g/kg with dose-relativity. Conclusion： FZY has effect on relieving withdrawal symptoms of morphine-dependent rat with the possible mechanism of down regulation the level of NO by inhibiting NOS activity in vivo.

关 键 词：扶正口服液 吗啡依赖 戒断症状 一氧化氮 一氧化氮合成酶 

分 类 号：R285.5[医药卫生—中药学]