缬沙坦联合阿魏酸钠治疗慢性肾功能衰竭疗效观察  

Clinical observation of the effect of valsartan combined with Sodium Ferulate in the treatment of the chronic renal failure

作　　者：曾春艳 周晓明 

机构地区：[1]呼伦贝尔市人民医院,内蒙古呼伦贝尔021008 [2]呼伦贝尔市药品检验所,内蒙古呼伦贝尔021008

出　　处：《中国医药导报》2007年第11X期27-28,共2页China Medical Herald

摘　　要：目的:观察缬沙坦、阿魏酸钠合用延缓慢性肾功能衰竭(CRF)进展的疗效。方法:90例CRF患者分为治疗组和对照组。治疗组给予缬沙坦和阿魏酸钠;对照组给予钙离子拮抗剂等降压药,均未服用或未坚持服用肾素-血管紧张素转换酶抑制剂(ACEI)或血管紧张素Ⅱ受体拮抗剂(ARB)。观察患者血压、尿蛋白定量、血尿素氮(BUN)、血肌酐(Scr)及肾小球滤过率(GFR)。结果:两组治疗后血压均下降;治疗组尿蛋白定量、BUN、Scr水平较对照组下降,GFR组较对照组增加,差异有显著性(P<0.05)。结论:缬沙坦联合阿魏酸钠能有效延缓CRF进展。Objective：To investigate the effect of valsartan combined with Sodium Ferulate in the treatment of chronic re nal failure（CRF）. Methods： 90 patients with CRF were divided into two groups; the treatment group was given with valsartan and Sodium Ferulate ; the control group was given with calcium channel blocker （CCB）, and other antihypertensive. Blood pressure, urinary protein, BUN, serum creatinine and glomerular filtration gate （GFR） of the patients were observed. The period of observation was 12-15 months. Results： The blood pressure of two groups was decreased. Compared with the control group, the urinary protein, BUN, serum creatine of the treatment group decreased more significantly, and the GFR increased （P〈0.05）, Conclusion： Valsartan combined with Sodium Ferulate can delay the progression of CRF.

关 键 词：肾功能衰竭 慢性 缬沙坦 阿魏酸钠 

分 类 号：R69[医药卫生—泌尿科学]