显微镜下多血管炎1例报道并文献复习  

One case of microscopic polyangiitis and literature review

作　　者：王美[1] 刘淑红[1] 胡晓玲[1] 程兆忠[1] 

机构地区：[1]青岛大学医学院附属医院呼吸科,266003

出　　处：《国际呼吸杂志》2007年第22期1693-1695,共3页International Journal of Respiration

摘　　要：目的探讨显微镜下多血管炎的诊断与治疗。方法本研究包括1例我院呼吸科收治的显微镜下多血管炎住院病例，结合文献分析其临床表现、影像学、诊断和治疗方法。结果显微镜下多血管炎是少见的一种原发性血管炎，最常见的症状是发热、高血压、肾功能不全、咳嗽、咯血、气短、肺功能下降等，诊断主要有赖于动脉造影和病理活检，显微镜下多血管炎的病理学特点是坏死性小血管炎，以肾、肺受累多见。结论显微镜下多血管炎的临床表现无特异性，影像学检查在其诊断中起重要作用，肾活检是显微镜下多血管炎区别于其它血管炎的鉴别要点，早期皮质激素和免疫抑制剂的应用能显著改善患者的预后。Objective To describe the approaches in diagnosis and treatment of microscopic polyangiitis （MPA）. Methods The study included one patient with MPA confirmed by clinical and histopathological studies. Results The patient was admitted to the department. The clinical data was analyzed, and related literature was reviewed. The clinical, radiological and pathological characteristics, and the approaches in diagnosis and treatment, presentations including fever, hypertension, renal insufficiency, cough,haemoptysis, dyspnea, pulmonary function injury et al were summarized. The diagnosis relys on angiography and histopathological study. The histological feature of MPA included necrotising small vasculitis,especially affected renal and lung. Conclusions The clinical manifestations of MPA are nonspecific. Radiography plays a pivotal role in diagnosis of MPA. The renal biopsy can help us to distinguish MPA from other vasculitis. Early administration of corticosteroids and immune suppressors may significantly improve the prognosis of the patients.

关 键 词：显微镜下多血管炎 诊断 治疗 

分 类 号：R5[医药卫生—内科学]