谷氨酰胺在急性肺损伤／急性呼吸窘迫综合征时发挥肺保护作用的研究进展  

Lung-protective mechanism of glutamine in acute lung injury/acute respiratory distress syndrome

作　　者：朱英[1] 邱海波[1] 

机构地区：[1]东南大学医学院附属中大医院危重医学科,东南大学急诊与危重病研究所,南京210009

出　　处：《国际呼吸杂志》2007年第22期1723-1726,共4页International Journal of Respiration

摘　　要：肺泡上皮细胞和肺毛细血管内皮细胞损伤、肺间质和肺泡水肿液积聚，从而影响气血交换，是急性肺损伤／急性呼吸窘迫综合征（acute lung injury／acute respiratory distress syndrome，ALI／ARDs）顽固性低氧血症的重要病理生理学基础。谷氨酰胺（glutamine，GLN）诱导热休克蛋白表达，通过热休克蛋白保护细胞和调节炎症反应的机制发挥肺保护作用。此外，GLN还具有保护肠道生理屏障、调节免疫反应、对抗氧化应激和营养支持作用，这些功能在ALI／ARDS的预防和治疗中均有重要意义。Injury of pulmonary epithelial and endothelial cell, pulmonary edema both in interstitium and alveoli leads gas-blood exchange to decrease, which is the pathophysiologic foundation of refractory hypoxemia of acute lung injury/acute respiratory distress syndrome （ALI/ARDS）. Glutamine protects the lung by inducing expression of heat shock protein, which protects the cells and adjusts inflammation. Besides, glutamine with features protecting intestinal barrier,adjusting immunological reaction,antagonizing oxidative stress, providing nutritional support, plays an important part in the prevention and cure of ALI/ARDS.

关 键 词：谷氨酰胺 急性肺损伤/急性呼吸窘迫综合征 热休克蛋白 

分 类 号：R563[医药卫生—呼吸系统]