下肢动脉粥样硬化性闭塞症患者体内微量元素浓度的变化  

Changes of trace elements' levels in patients with atherosclerosis obliterans of lower limb

作　　者：梁卫[1] 张柏根[1] 张纪蔚[1] 刘苏征[1] 洪孝诒 

机构地区：[1]上海第二医科大学仁济医院,200001 [2]上海测试技术研究所

出　　处：《上海医学》1997年第7期385-387,共3页Shanghai Medical Journal

摘　　要：选择23例下肢动脉粥样硬化性闭塞症（ASO）患者，用中子活化分析法测定血清及头发中微量元素的浓度。所得结果发现：1．病例组中血清与头发微量元素钒浓度较对照组明显降低；2血清钢浓度较对照组明显升高；3．头发锰浓度较对照组明显降低。结果表明体内微量元素钒、铜和锰的浓度的异常与ASO的发生有关。应用逐步判别分析方法，分别建立以研究对象血清微量元素钒、铜以及头发钒浓度作为变量的疾病判别方程式，总符合率分别达到80．0％和77．5％，可能作为诊断ASO的初步筛选手段。Twenty-three cases of Atherosclerosis Obliterans(ASO) were investigated in the study. Levels of traceelements in serum and hair were determined using neutron activation analysis. The results are summarized as follows:l. The levels of vanadium(V) in serum and hair were significantly lower copper (Cu) in serum was higher and manganese (Mn) in hair was lower in the ASO group compared with controls. It showed that the levels of V, Cu and Mnwere related to the occurrence of ASO. 2. The stepwise discriminative analysis of factors affecting the occurence of ASOresulted in the equation which consisted of levels of V and Cu in serum, V in hair respectively. The coincident ratesreached 80. 00% and 77. 50%. It implies that the levels of trace elements could be of great help t0 the clinical diagnosisof the disease.

关 键 词：微量元素 下肢 动脉粥样硬化性 闭塞症 

分 类 号：R543.502[医药卫生—心血管疾病]