双能X射线骨密度仪测量不同条件下腰椎骨矿含量、椎骨骨面积有临床意义的最小变化率  

Minimal change rate of bone mineral density and vertebral area with clinical significance detected by dual-energy X-ray bone densitometer

作　　者：康后生[1] 孙昆[1] 任伶俐[1] 江毅敏[1] 邱平[1] 

机构地区：[1]川北医学院附属医院内分泌科,四川省南充市637000

出　　处：《中国组织工程研究与临床康复》2007年第44期8903-8907,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:骨密度仪的差异或漂移可以通过质控加以校正。比较双能X射线骨密度仪测量腰椎铝体模、活体腰椎、死体腰椎(带软组织)的骨矿含量、椎骨骨面积有临床意义的最小变化率差异,以便为重复测量同一个体的骨矿含量或骨密度评估临床药物疗效提供依据。方法:实验于2004-05/2006-12在川北医学院人体解剖实验室与川北医学院附属医院内分泌科骨密度室完成。采用美国Lunar公司生产的DPX-MD双能X射线骨密度仪测量铝体模、3个活体椎体、1个带软组织的死体椎体的骨矿含量与椎骨骨面积,3次/d,连续测定5d。3个活体椎体分别为38岁骨密度正常男性、40岁骨质疏松症男性及62岁轻微骨量减少女性的椎体,均为自愿参与实验的本院医生。死体椎体由川北医学院人体解剖实验室提供。实验得到医院伦理道德委员会批准。计算各椎体骨矿含量、椎骨骨面积的变异系数及有临床意义的最小骨矿含量、椎骨骨面积变化率。结果:①有临床意义的最小骨矿含量变化率:铝体模与正常男性椎体最小,骨质疏松症男性椎体、轻微骨量减少女性椎体与死体椎体呈依次增大趋势,且以死体椎体最大。②有临床意义的最小椎骨骨面积变化率:铝体模、正常男性椎体与骨质疏松症男性椎体最小,轻微骨量减少女性椎体与死体椎体较大,且以死体椎体最大。结论:双能X射线骨密度仪测量不同条件椎骨有临床意义的最小骨矿含量、椎骨骨面积变化率存在差异,骨质疏松的严重程度不同,骨矿含量、椎骨面积骨密度检测对临床药物疗效观察的影响不同,骨质疏松越严重或有骨质增生的存在对其影响越大。AIM： The discrepancy or drift in bone densitometers could be corrected by quality control. In this study, the difference of change rate of bone mineral density minimum with clinical significance was compared after measuring bone mineral density （BMD） of aluminum model of lumbar vertebra, live lumbar vertebra and dead lumbar vertebra （with soft tissue） with DPX-MD dual-energy X-ray bone densitometer, so as to provide evidence for the evaluation of the clinical curative effect of drug by repetitively measuring the BMD or bone density in the same individual. METHODS： The experiment was conducted in the Department of Endocrinology, Affiliated Hospital and Human Anatomy Laboratory of North Sichuan Medical College from May 2004 to December 2006. DPX-MD dual energy X-ray absorptiometry （Lunar, U.S） was used to measure the BMD and vertebral area of aluminum model, 3 live lumbar vertebras, and 1 dead lumbar vertebra with soft tissue, 3 times daily for 5 days. The 3 live lumbar vertebras were from one normal 38-year-old male, one 40-year-male with osteoporosis, and one 62-year-old female with decreased bone mass. They were the volunteer doctors. The dead lumbar vertebra was provided by the Human Anatomy Laboratory of North Sichuan Medical College. The experiment was permitted by the Hospital Ethics Committee. The coefficient of variance of BMD and vertebral area, and the minimal BMD and vertebral area that presented clinical significance were calculated. RESULTS： ①The change rate of minimal BMD in aluminum model and normal male lumbar vertebra was the minimum; the rate in lumbar vertebra of osteoporotic male, bone mass decreased female and dead body was increased by turns. ②The change rate of the minimal vertebral area that had clinical significance in the lumbar vertebra of aluminum model, normal male and osteoporotic male was the minimum, while in the lumbar vertebra of bone mass decreased female and dead body was larger, especially in dead body. CONCLUSION： There are differences in the mini

关 键 词：骨密度 腰椎 光密度测定法 

分 类 号：R681[医药卫生—骨科学]