细胞极性蛋白复合物PAR/aPKC的研究进展  

Research Advance on a Protein Complex PAR/aPKC in Cell Polarity

作　　者：边文杰[1] 陈晓萍[1] 

机构地区：[1]浙江工业大学生物与环境工程学院,浙江杭州310014

出　　处：《生物技术通讯》2007年第6期995-997,共3页Letters in Biotechnology

基　　金：国家人事部留学择优基金项目;浙江省自然科学基金项目(Y204183)

摘　　要：不对称细胞分裂是动物发育过程中用以调控细胞分化的一种进化上保守的基本模式。极性的祖细胞通过不对称分裂产生两个不同命运的子细胞,这一过程涉及细胞命运决定因子的不对称分布、纺锤体的旋转定位等,而这些过程都必须依赖特定细胞极性的存在才能得以正常进行。简要综述了高度保守的蛋白复合物PAR/aPKC在细胞极性建立和维持中的重要作用,以及它如何调控纺锤体定位和命运决定因子不对称分配,并讨论了在该领域的一些新发现和研究进展。Asymmetric cell division is a fundamental pattern regulating cell differentiation during animal development and is also conserved in evolution. A polarized progenitor gives rise to two daughter cells with different fates through the asymmetric division which involves the asymmetric distribution of cell fate determinants and the orientation of the mitotic spindle. Both processes need the presence of certain cell polarity. In this paper, how PAR/aPKC complex, a highly conserved protein complex, functions in the establishment and maintenance of cell polarities as well as in the regulation of deterninants distribution and mitotic spindle orientation were reviewed, and some recent findings and progresses in this field were also discussed.

关 键 词：PAR/aPKC复合物 细胞极性 命运决定因子 纺锤体定位 

分 类 号：Q26[生物学—细胞生物学] Q25