DCC／DMAP法合成二茂铁基苯甲酸胆甾醇酯  

Synthesis of cholesteryl ferrocenyl benzoate via DCC/DMAP condensation

作　　者：韩相恩[1] 张术兵[1] 屈崎超[1] 杨利华[1] 

机构地区：[1]兰州交通大学化学与生物工程学院,甘肃兰州730070

出　　处：《功能材料》2007年第A01期247-249,共3页Journal of Functional Materials

基　　金：基金项目：甘肃省自然科学基金资助项目（3Z-S042-B25-041）;兰州交通大学青蓝基金资助项目（QL-05-17A）

摘　　要：倒重氮法合成两类二茂铁基苯甲酸，继而研究以N，N-二环己基碳二亚胺（DCC）作脱水剂，用4-二甲胺基吡啶（DMAP）作除水促进剂，胆甾醇与间、对-二茂铁苯甲酸反应合成液晶材料间、对-二茂铁基苯甲酸胆甾醇酯的方法。研究结果表明，该方法反应条件比较温和，用DMAP作除水促进剂时，胆甾醇酯产率比较高。高效酰化催化剂法是十分有效的酰化方法，在合成胆甾醇酯液晶中可较大幅度地提高产品的产率与纯度，简化操作，降低反应毒性。Two kinds of ferrocenyl benzoic acid is synthesized by converse diazotization, then, using N, N-dicyclohexylcarbodiimide （DCC） as dehydrating agent, and 4-dimethylamin-pyridine （DMAP） as dehydration accelerant, the synthesis of liquid crystal material Cholesteryl m, p-ferroenyl benzoate are prepared. The research results showed that the reaction condition of the method was mild, the yield when DMAP as dehydration accelerant was higher than the others. Also the DMAP is an effective catalyst to synthesize cholesteryl ester compounds, In the reactions, improving yield and purity, reducing toxicity as well as simplifying operation process can be carried out.

关 键 词：二茂铁 胆甾醇酯 倒重氮法 DCC/DMAP 

分 类 号：O621.25[理学—有机化学]