低温诱发肉鸡腹水综合征发生过程中肺血管重塑与肺动脉高压的关系  

Relationship between pulmonary vascular remodeling and pulmonary arterial pressure in ascites syndrom induced by low ambient temperature in broilers

作　　者：王建琳[1] 乔健[1] 赵立红[1] 张建军[1] 利剀[1] 王慧煜[1] 徐彤[1] 田勇[1] 

机构地区：[1]中国农业大学动物医学院,北京100094

出　　处：《中国兽医学报》2007年第6期874-878,共5页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金资助项目(30070567;30571398)

摘　　要：将160只15日龄雄性AA商品代肉鸡随机分为对照组（（22±1．5）C）和低温组（（11±2）C）。15～50日龄，每组每周随机取6只，以右心导管法直接测定肺动脉压（PAP），并取肺组织做石蜡切片进行Weigert-间苯二酚复红染色，分析肺血管重塑情况。50日龄时统计整个饲养过程中肉鸡腹水综合征（AS）发生率。结果显示，低温组肉鸡AS发生率（18．75％）极显著高于对照组（1．25％）（P〈0．01）；低温组肉鸡PAP从22日龄开始较对照组明显升高（P〈0．01或P〈0．05）；20～50、50～100、100～200μm肺动脉结构分别从36、43、43日龄开始较对照组发生了明显的重塑（P〈0．01或P〈0．05）。结果表明，低温诱发肉鸡AS过程中出现了明显的PAP升高和肺血管重塑，且肺动脉高压（PH）促进了肺血管重塑，肺血管重塑加剧了PAP升高。One hundred sixty 15-day-old Arbor Acre male commercial broiler chickens were randomly allocated into control group （（22±1. 5） C ） and low temperature group （（11 ± 2） C ）. Six broilers were randomly taken from each group every week from 15 to 50 days of age to measure the pulmonary arterial pressure （PAP） and pulmonary vascular remodeling. The higher incidence （18. 75%） of AS was induced by low ambient temperature, PAP was significantly elevated in low temperature group from 22 to 50 days of age （P 〈 0.01 or P 〈 0. 05）. Pulmonary arteries with 20-50, 50-100, 100-200 μm diameter were remodeled from 36, 43 and 43 to 50 days of age separately as compared with those in the control group （P 〈 0.01 or P 〈 0.05）. Our study demonstrated that PAP increased and pulmonary artery remodeled in the development of AS in broilers, which suggest that increase of the PAP promotes pulmonary vascular remodeling and pulmonary vascular remodeling facilitates the increase of PAP.

关 键 词：腹水综合征 肺动脉高压 肺动脉重塑 肉鸡 

分 类 号：S852.35[农业科学—基础兽医学]