TiN／Ag多层膜的生物相容性研究  

A study on biocompatibility of TiN/Ag multilayered coatings

作　　者：才学敏[1] 唐慧琴[1] 刘桐[1] 赵杰[1] 刘欣[2] 万荣欣[2] 顾汉卿[2] 

机构地区：[1]天津师范大学物理与电子信息学院,天津300387 [2]天津市泌尿外科研究所,天津300221

出　　处：《功能材料》2007年第A05期1828-1831,共4页Journal of Functional Materials

基　　金：国家自然科学基金资助项目（10475061）;天津市自然科学基金资助项目（033607911）

摘　　要：使用离子束辅助沉积（IBAD）的方法，在医用不锈钢317L的基底上制备TiN／Ag多层膜．在TiN／Ag多层膜具有良好的抗茵性和抗腐蚀性的研究基础上，通过细胞毒性试验和溶血试验评价了TiN／Ag多层膜的生物相容性．试验结果表明：TiN／Ag多层膜样品的细胞毒性等级在0～1之间；溶血率〈5％，符合生物医学材料的标准．这些说明TIN／Ag多层膜不仅具有抗菌性和抗腐蚀性，而且具有良好的生物相容性．TiN/Ag multilayered coatings are made on medical stainless steel 317L by ion beam assisted deposition method Based on our previous results such as antibacterial and anticorrosive properties of TiN/Ag multilayers, the biocompatibility is investigated by cell cytotoxicity and hemolysis tests. The results show that the cytotoxicity of TiN/Ag multilayers is ranked at grade of 0- 1; hemolysis ratio is less than 5% which are in the scope of the standard of biomedical materials. The results indicate TiN/Ag multilayered coatings not only have antibacterial property and anticorrosive property, but also have good biocompatibility.

关 键 词：多层膜 细胞毒性 溶血 

分 类 号：R318.08[医药卫生—生物医学工程]