主动靶向5-氟尿嘧啶聚乳酸微球的研究  

Study on voluntary-targeting 5-fluorouracil loaded PLA microspheres

作　　者：乔馨乐[1] 袁华[1] 韩君[1] 任杰[1] 

机构地区：[1]同济大学材料科学与工程学院 纳米与生物高分子材料研究所,上海200092

出　　处：《功能材料》2007年第A05期1931-1934,共4页Journal of Functional Materials

基　　金：上海市纳米科技专项基金资助项目（0452nm059）：上海市重大基础研究基金资助项目（05DJ1046）

摘　　要：通过对5-u聚乳酸载药微球接PEI进行表面胺解、接枝靶向基团Folate以及荧光物质FITC，制备了靶向5-u聚乳酸微球，并研究了微球的缓释性能、荧光效应和主动靶向性．结果表明，靶向5-u聚乳酸微球具有良好的缓释性能，缓释时间可达到105h；未改性的载药微球对Hela细胞的抑制作用有限，无主动靶向性：改性的载药微球具有明显的荧光效应和良好的主动靶向性．Targeting 5-Fu loaded PLA rrucrospheres were prepared by grafting PEI, Folate, and FITC. The properties such as sustained release, fluorescent effect and voluntary-target were studied. The results showed that the release time was extended to 105h with good sustained release property. The inhibitory effect and the voluntary-target capacity of unmodified drug-loaded microspheres were poor. However, the modified drug-loaded rrucrospheres had superior fluorescent effect and voluntary-target capacity.

关 键 词：聚乳酸 缓释 荧光效应 靶向 

分 类 号：R318.08[医药卫生—生物医学工程]