聚乳酸头孢唑啉钠微球的制备及其性能表征  

Preparation and characterization of polylactic acid-cefazolin sodium microspheres

作　　者：冯晓健[1,2] 卢文庆[1,2] 王伟[1,2] 赵敏[1] 

机构地区：[1]南京师范大学化学与环境科学学院,江苏南京210097 [2]南京大学固体微结构物理国家重点实验室,江苏南京210093

出　　处：《功能材料》2007年第A05期1968-1970,共3页Journal of Functional Materials

基　　金：南京大学固体微结构物理国家重点实验室资助项目（M05010）

摘　　要：采用复乳法制备聚乳酸．头孢唑啉钠（PLA-CEZ）微球．扫描电子显微镜（SEM）和差热分析（DTA）结果表明，PLA-CEZ呈现完整的球形且聚乳酸和模型药物能够有机地结合为一体．同时，探讨了聚乳酸分子量大小及释药介质对载药微球释放速度的影响；释药曲线显示，PLA-CEZ微球具有很好的缓释效果．The different molecular weight PLA-CEZ microspheres were prepared successfully with the double emulsion method. The results of scanning electron microscope （SEM） and the differential themal analysis （DTA） demonstrated that the. PLA-CEZ microspheres were spherical, polylactic acid and cefazolin sodium mingled together. Effects of molecular weight of PLA and medium on the drug-releasing performance of the PLA microspheres were also investigated. Drug-releasing curve indicated that the PLA-CEZ microsphere has sustained release character.

关 键 词：复乳法 聚乳酸 头孢唑啉钠 微球 药物 缓释 

分 类 号：R318.08[医药卫生—生物医学工程]