皮内法接种重组(酵母)乙型肝炎疫苗免疫效果分析  

Efficacy of Recombinant Yeast-derived Hepatitis B Vaccine Endermic Vaccination

作　　者：张红利 张贵新 邹玉兰 

机构地区：[1]四川省科学城疾病预防控制中心,四川绵阳621900

出　　处：《预防医学情报杂志》2007年第5期532-533,共2页Journal of Preventive Medicine Information

摘　　要：目的了解皮内法接种重组(酵母)乙型肝炎疫苗的接种效果、接种副反应。方法用重组(酵母)乙型肝炎疫苗对15例肌肉注射无应答者实施1个程序的皮内接种,2周接种1次,每次5μg,4次为一程序,观察接种后72h内局部反应和全身反应,检测接种后1个月、2个月的血清抗-HBs阳转率。结果接种皮丘直径大小在0.8～1.3cm之间,皮丘消失时间45～120min,接种局部反应发生率6.8%,主要是瘙痒、压痛等一过性反应,未进行治疗于72h内自行恢复,无皮疹、体温升高等全身性反应。接种后1个月、2个月血清抗-HBs阳转率分别为66.7%和86.7%,男、女总阳转率差异无统计学意义(χ2=0.043,P>0.05)。结论皮内法接种重组(酵母)乙型肝炎疫苗是安全有效的,可作为提高应答率的方法之一。Objective To understand the immunogenicity and potential adverse effects of recombinant yeast-derived hepatitis B vaccine（YDV）endermic vaccination in health adult volunteers who had non-responsiveness after one,two or three schedules intramuscular vaccination.Methods Fifteen volunteers were given 5 μg/dose of endermic vaccination once every 2 weeks for 4 times.The potential adverse effects were observed within 72 hours after vaccination,and the serum samples were collected for testing anti-HBs at 1 and 2 months after vaccination.Results The result showed that the diameter of the skin hillock ranged 0.8 cm to 1.3 cm,and disappeared after 45-120min.The local reaction were slight with a rate of 6.8% and disappeared without treatment within 72 hours.No skin rash,fever etc.systemic adverse reactions were found.One and two months after full dose immunization,the anti-HBs positive rate of endermic vaccination was 66.7% and 86.7%.There were no significant differences on sero-conversion rate among men and women（χ2=0.043,P〉0.05）.Conclusion These results clearly demonstrate that YDV endermic vaccination had excellent safety and immunogenicity and maybe feasible for expanded.

关 键 词：皮内接种 重组(酵母)乙型肝炎疫苗 抗-HBS 朗罕氏细胞 

分 类 号：R512.62[医药卫生—内科学] R186[医药卫生—临床医学]