美托洛尔对老年高血压患者血浆纤溶功能的影响  

Effects of Metoprolol on the Fibrinolytic System in Aged Patients with Hypertension

作　　者：朱云[1] 段翠琴[2] 李辰成[1] 

机构地区：[1]河南医科大学第一附属医院老年病科,郑州450052 [2]渑池县人民医院内科

出　　处：《河南医学研究》1997年第3期240-241,共2页Henan Medical Research

摘　　要：目的:观察美托洛尔对高血压患者血浆纤溶功能的影响。方法:51例老年原发性高血压患者,随机分成两组,在应用降压药物的基础上分别加用安慰剂和小剂量β_1阻滞剂美托洛尔治疗,时间8周,并于用药前后测定血浆纤溶活性(tPA)及其抑制物(PAI)和左室射血分数(EF)。结果:美托洛尔组血浆纤溶活性及左室功能明显增强。结论:β_1阻滞剂对改善患者血浆纤溶异常状态,阻止血栓进一步形成,防止疾病的进展有肯定的作用。Objective:To observe the effects of metopmlol on the fibrinolytic system in aged patients with hypertension.Methods:Fifty one aged patients with essential hypertension(EH)were randomized to receive metopmlol(beta 1-selective adrenoceptor blocker)and placebo in a double-blind study 8 weeks. Tissue plasminogen activator(tPA)and Plasminogen activator inhibitor(PAI-1)and ejection fraction(EF) were measured in citrated plasma samples before and at the end of the study period.Results:Left ventricu- lar function,tPA and PAI activity were significantly increased and decreased after metopmlol as compared to pretreatment values.The fibrinolytic variables did not change in the placebo group.Conclusion:Meto- pmlol improved the activity of the fibrinolytic system in patients with hypertension.

关 键 词：高血压 纤溶活性 美托洛尔 老年人 

分 类 号：R972.2[医药卫生—药品] R544.105[医药卫生—药学]