补铬(Ⅲ)对糖尿病大鼠体内铬、锌、铜含量的影响  

EFFECT OF CHROMIUM( Ⅲ) SUPPLEMENTATION ON THE CONTENT OF Cr,Zn,Cu IN STZ INDUCED DIABETIC RATS

作　　者：吴建峰[1] 陈清[1] 高兆华[1] 王耐芬[1] 王小燕[1] 

机构地区：[1]北京医科大学公共卫生学院

出　　处：《营养学报》1997年第2期191-195,共5页Acta Nutrimenta Sinica

摘　　要：分别用原子吸收石墨炉法和原子吸收火焰法对链脲佐菌素诱导的糖尿病大鼠经灌胃给予富铬酵母后体内血（或血清）、肝、肾中铬、锌、铜的含量进行了三周的观察。结果表明：在整个观察期间，与正常大鼠相比，糖尿病大鼠肝铬含量升高、肾铬含量下降；肝、肾中的锌、铜、血清铜含量均呈不同程度的升高；对糖尿病大鼠灌以富铬酵母３０μｇＣｒ３＋／ｋｇｂｗ（以总铬计），虽未使糖尿病大鼠的血糖情况有所改善，但可使糖尿病大鼠升高了的肝铬及血铜下降而趋于正常，且其大鼠的生长情况也好于糖尿病对照组。因而，对糖尿病大鼠补充一定剂量的铬（Ⅲ）可能对其有一定的保护作用。The content of Cr,Zn,Cu in blood (or serum),liver,and kidney from streptozotocin induced diabetic rats had been observed for 3 weeks by means of GFAAS and FAAS after being given Cr-rich brewers yeast by gavage.The results showed that the content of Cr was higher in liver and lower in kidney as compared with normal.The concentration of Cu in serum and Zn and Cu in liver and kidney was higher than that of normal in different degrees.Although 30μg Cr 3+ /kg bw of Cr-rich brewers yeast had no effect on plasma glucose in diabetic rats,it could reduce liver Cr and serum Cu to normal level and it also indicated that these rats grew better than those diabetic rats not given Cr-rich brewers yeast.These findings suggest that a certain dose of Cr (Ⅲ) given to the diabetic rats may have some protective effect.

关 键 词：糖尿病 富铬酵母 铬 锌 铜 

分 类 号：R587.1[医药卫生—内分泌] R151.2[医药卫生—内科学]