喹诺酮类药物的降解物结构确证  

The Structure Identification of Degradation Product of Quinolone Drugs

作　　者：顾慧儿[1] 孙兰英[1] 吴香玫[1] 陶珍[1] 赵淑敏[1] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所

出　　处：《药物分析杂志》1997年第2期89-92,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：氧氟沙星、盐酸洛美沙星及氟罗沙星在２ｍｏｌ／Ｌ盐酸液中长时间加热回流，分离纯化后所得的降解物，经ＭＳ、１ＨＮＭＲ、１３ＣＮＭＲ、ＩＲ及ＵＶ测试与解析，并与原药比较，确证它们是原药的脱羧物。Ofloxacin,lomefloxacin and freloxacin were degraded by refluxing in 2mol/L hydrochloric acid solution for a long period of time.The degradation products were isolated and identified by MS、UV、IR and NMR spectra as decarboxylates.

关 键 词：喹诺酮类药物 降解物 结构 

分 类 号：R978.1[医药卫生—药品]